PMID: 9539790May 16, 1998Paper

In vivo evidence that erythropoietin protects neurons from ischemic damage

Proceedings of the National Academy of Sciences of the United States of America
M SakanakaR Sasaki

Abstract

Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO. EPO has been shown to protect primary cultured neurons from N-methyl-D-aspartate (NMDA) receptor-mediated glutamate toxicity. Here we report in vivo evidence that EPO protects neurons against ischemia-induced cell death. Infusion of EPO into the lateral ventricles of gerbils prevented ischemia-induced learning disability and rescued hippocampal CA1 neurons from lethal ischemic damage. The neuroprotective action of exogenous EPO was also confirmed by counting synapses in the hippocampal CA1 region. Infusion of soluble EPOR (an extracellular domain capable of binding with the ligand) into animals given a mild ischemic treatment that did not produce neuronal damage, caused neuronal degeneration and impaired learning ability, whereas infusion of the heat-denatured soluble EPOR was not detrimental, demonstrating that the endogenous brain EPO is crucial for neuronal survival. The presence of EPO in neuron cultures did not repress a NMDA receptor-mediated increase in intracellular Ca2+, but rescued the neurons from NO-induced death. Taken togeth...Continue Reading

Associated Clinical Trials

References

Oct 30, 1992·Biochemical and Biophysical Research Communications·M NagaoR Sasaki
Apr 1, 1992·Physiological Reviews·W Jelkmann
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Jan 1, 1988·Annals of the New York Academy of Sciences·B K Siesjö
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R S MorrisonR A Bradshaw
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M DigicayliogluM Gassmann
Oct 28, 1994·Biochemical and Biophysical Research Communications·A SanoM Sakanaka
Jul 1, 1996·Physiological Reviews·H F Bunn, R O Poyton
May 1, 1996·Journal of Neurochemistry·Y KotaniA Sano
Apr 1, 1996·The European Journal of Neuroscience·H H MartiM Gassmann

❮ Previous
Next ❯

Citations

Jan 2, 2003·Annals of Neurology·Marc Fisher, Rajiv Ratan
Jun 7, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Liang YeJiang Ping
Mar 15, 2012·Cellular and Molecular Life Sciences : CMLS·Mauro W Zappaterra, Maria K Lehtinen
Sep 29, 2011·Psychopharmacology·Kamilla W MiskowiakLars V Kessing
Mar 19, 2005·European Journal of Clinical Pharmacology·Anargyros XenocostasHans A Messner
Sep 11, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yisheng ZhongXiaoqing Zhou
Feb 27, 2008·Langenbeck's Archives of Surgery·J A LohmeyerH G Machens
Mar 21, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Abdurrahman CetinGönül Olmez
Dec 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Edith HochhauserZiv Ben-Ari
May 27, 2008·Cardiovascular Drugs and Therapy·Ferdinand H Bahlmann
May 4, 2011·Cellular and Molecular Neurobiology·Arthur J Sytkowski
Feb 3, 2012·Cellular and Molecular Neurobiology·Neetu SinghVikas Mishra
Nov 13, 2008·Cytotechnology·Masaya NagaoMasahiro Sakanaka
Feb 1, 2008·Heart Failure Reviews·Roberto LatiniFabio Fiordaliso
Oct 31, 2008·Journal of Assisted Reproduction and Genetics·Hiroshi SuzukiHideki Saitoh
Sep 24, 2013·Molecular and Cellular Biochemistry·Guo-Bin WangWei-Fang Zhang
Nov 24, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hongcan ZhuYuming Xu
Jun 12, 2004·Current Atherosclerosis Reports·Samit MalhotraDaniel M Rosenbaum
Feb 26, 2013·Current Treatment Options in Neurology·Claudia Robertson, Saeed Sadrameli
Jan 31, 2004·Biochemical and Biophysical Research Communications·Cheng-Haung WangKuo-Sheng Hung
Jun 7, 2005·Molecular and Cellular Neurosciences·Alexandra KretzStefan Isenmann
Jun 7, 2005·Neurobiology of Disease·Astrid WeberChristoph Bührer
Jun 2, 2005·Neurotoxicology·Stefano BartesaghiBarbara Viviani
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna-Leena SirénHannelore Ehrenreich
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yanxin Zhao, David A Rempe
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Jesper MogensenHana Malá
Aug 26, 2003·The American Journal of Pathology·Zishan A HaroonMurat O Arcasoy
Jul 25, 2003·Biochemical and Biophysical Research Communications·Murat O ArcasoyZishan A Haroon
Aug 21, 2003·Biochemical and Biophysical Research Communications·Anthony F TramontanoNabil El-Sherif

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M BrinesAnthony Cerami
Proceedings of the National Academy of Sciences of the United States of America
A L SirénPietro Ghezzi
The European Journal of Neuroscience
H H MartiMax Gassmann
Proceedings of the National Academy of Sciences of the United States of America
M DigicayliogluMax Gassmann
© 2022 Meta ULC. All rights reserved