PMID: 9525586Apr 3, 1998Paper

In vivo evolution of a novel, syncytium-inducing and cytopathic feline leukemia virus variant

Journal of Virology
J L RohnJ Overbaugh

Abstract

Studies of feline leukemia virus (FeLV) have illustrated the importance of the genotype of the infecting virus in determining disease outcome. In FeLV infections, as in other retroviral infections, it is less clear how virus variants that evolve from the transmitted virus affect pathogenesis. We previously reported an analysis of the genotypic changes that occur in the viral envelope gene (env) in cats infected with a prototype transmissible FeLV clone, 61E (J. Rohn, M. Linenberger, E. Hoover, and J. Overbaugh, J. Virol. 68:2458-2467, 1994). In one cat, each variant (81T) had evolved, in addition to scattered amino acid changes, a four-amino-acid insertion with respect to 61E. This insertion was located at the same site in the extracellular envelope glycoprotein where the immunodeficiency-inducing molecular clone 61C possesses a six-amino-acid insertion critical for its pathogenic phenotype, although the sequences of the insertions were distinct. To determine whether acquisition of the four-amino-acid insertion was associated with a change in the replication or cytopathic properties of the virus, we constructed chimeras encoding 81T env genes in a 61E background. One representative chimeric virus, EET(TE)-109, was highly cytopa...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Nov 6, 1992·Science·J M White
Mar 1, 1992·AIDS Research and Human Retroviruses·H FeichtingerP Biberfeld
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S C Fields-BerryC L Cepko
Jan 1, 1991·Journal of Virology·R Aronoff, M Linial
Jul 1, 1989·The Journal of General Virology·K B Andersen, H Skov
Mar 1, 1988·Reviews of Infectious Diseases·H M Temin
Mar 1, 1986·Journal of Virology·A PinterS Silagi
Dec 1, 1970·Virology·W P RoweJ W Hartley
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D G MillerA D Miller
Nov 1, 1996·Journal of Virology·J L RohnJ Overbaugh

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Citations

Dec 13, 2003·Journal of Virology·Zhaohui Qian, Lorraine M Albritton
May 5, 2004·The Journal of Biological Chemistry·Indranil DasJan Kitajewski
Mar 16, 2006·Journal of Virology·Ramon MendozaJulie Overbaugh
Oct 17, 2001·Journal of Virology·M M AndersonJ Overbaugh
Dec 14, 2007·Journal of Virology·Xiaoqing Zhao, Fayth K Yoshimura
Oct 28, 2004·Journal of Virology·Yong Tae JungChristine A Kozak
Feb 19, 2016·Journal of Virology·Ariko MiyakeKazuo Nishigaki
Dec 20, 2005·Veterinary Dermatology·C FavrotA Kipar
Dec 28, 2012·Journal of Virology·Ramon MendozaJulie Overbaugh
Apr 19, 2019·Journal of Virology·Ariko MiyakeKazuo Nishigaki
Jan 29, 2003·Journal of Virology·Anna L BarnettJames M Cunningham

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