PMID: 9659883Jul 11, 1998Paper

In vivo experiments with mesothelial cell seeded ePTFE vascular grafts

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
H J VerhagenB C Eikelboom

Abstract

To investigate the influence of mesothelial cell (MC) seeding on patency and neointimal formation of small diameter ePTFE grafts in a canine model. MC were isolated from the omentum, cultured, seeded on fibronectin-coated ePTFE grafts (4 cm, 4 mm ID), and implanted in the carotid artery of five Beagle dogs. Each dog also received a non-seeded control graft. Patency was assessed by palpation immediately after implantation, and non-invasively by magnetic resonance angiography (MRA) after 1 week and just prior to sacrifice (4 weeks). Intimal thickness was quantified on histological sections by use of computer-aided morphometry. All grafts were patent after implantation. After 1 week, MRA showed the loss of lumen diameter in two seeded grafts. After 4 weeks, two seeded grafts were occluded, one seeded graft was severely stenosed, and all others were without angiographic lumen reduction. Histology and morphometry confirmed that two seeded grafts were occluded, and demonstrated that the other three seeded grafts showed significantly more intima formation (0.22-1.34 mm) than the control grafts (< 0.08 mm; p < 0.01). The MC seeding process decreases patency and increases neointimal formation of small diameter ePTFE grafts in dogs and d...Continue Reading

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Citations

Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Sarah E Herrick, Steven E Mutsaers
Jul 6, 2000·American Journal of Surgery·K AkimaruS Mineta
May 30, 2001·American Journal of Surgery·M YoshiokaK Takubo
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Michel R HoenigJulie H Campbell
Sep 4, 1999·Endothelium : Journal of Endothelial Cell Research·L BordenaveD Midy
Sep 9, 2015·Frontiers in Bioengineering and Biotechnology·Christian Claude LachaudBernat Soria
Dec 26, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C H P ArtsB C Eikelboom
Dec 21, 2005·Pathologie-biologie·Dina S VaraAlexander M Seifalian
Jun 23, 2010·Clinical Orthopaedics and Related Research·German A MarulandaG Douglas Letson
Sep 1, 2016·Pleura and Peritoneum·Kunio Kawanishi
Jul 14, 2007·The International Journal of Artificial Organs·I ElmadbouhJ C Chachques

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