In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Retrovirology
Mineki SaitoYoshiro Ohara

Abstract

Recently, human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper factor (HBZ), encoded from a minus strand mRNA was discovered and was suggested to play an important role in adult T cell leukemia (ATL) development. However, there have been no reports on the role of HBZ in patients with HTLV-1 associated inflammatory diseases. We quantified the HBZ and tax mRNA expression levels in peripheral blood from 56 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 10 ATL patients, 38 healthy asymptomatic carriers (HCs) and 20 normal uninfected controls, as well as human leukemic T-cell lines and HTLV-1-infected T-cell lines, and the data were correlated with clinical parameters. The spliced HBZ gene was transcribed in all HTLV-1-infected individuals examined, whereas tax mRNA was not transcribed in significant numbers of subjects in the same groups. Although the amount of HBZ mRNA expression was highest in ATL, medium in HAM/TSP, and lowest in HCs, with statistical significance, neither tax nor the HBZ mRNA expression per HTLV-1-infected cell differed significantly between each clinical group. The HTLV-1 HBZ, but not tax mRNA load, positively correlated with disease severity and with neopterin concen...Continue Reading

References

Mar 1, 1992·Japanese Journal of Cancer Research : Gann·M MochizukiN Miyata
Feb 25, 1989·Lancet·K NishiokaM Osame
May 3, 1986·Lancet·M OsameM Tara
Sep 11, 1987·Science·S H HinrichsG Jay
Nov 21, 1987·Lancet·M SugimotoS Kawasaki
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J GrossmanLee Ratner
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·F UmeharaM Osame
Sep 16, 1998·Journal of Neuropathology and Experimental Neurology·F UmeharaM Osame
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·K J JefferyCharles R M Bangham
Feb 1, 2000·International Journal of Cancer. Journal International Du Cancer·K ArisawaS Shirahama
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J JefferyCharles R M Bangham
Mar 13, 2001·Annual Review of Immunology·M Yoshida
Mar 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yoshitaka FurukawaM Osame
Jul 29, 2005·Clinical and Laboratory Haematology·Shimeru KamihiraY Yamada
Sep 13, 2005·Oncogene·Charles R M Bangham, M Osame
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yorifumi SatouMasao Matsuoka
Mar 4, 2006·Retrovirology·Marie-Hélène CavanaghBenoit Barbeau
Nov 8, 2008·International Journal of Cancer. Journal International Du Cancer·Brenda M BirmannMichie Hisada

Citations

Apr 22, 2011·Bulletin of Mathematical Biology·Michael Y Li, Aaron G Lim
Nov 9, 2011·The Journal of Infectious Diseases·Estelle DouceronRenaud Mahieux
Jul 9, 2010·Clinical Microbiology Reviews·Denise Utsch GonçalvesAnna Bárbara F Carneiro-Proietti
Feb 5, 2010·Journal of Virology·Mads Heilskov RasmussenFinn Skou Pedersen
May 6, 2010·Veterinary Pathology·Bevin ZimmermanMichael D Lairmore
Aug 5, 2009·Retrovirology·Masao Matsuoka, Patrick L Green
Aug 14, 2009·Retrovirology·Rachel Van DuyneFatah Kashanchi
Oct 5, 2010·PLoS Pathogens·Aidan MacNamaraBecca Asquith
Feb 25, 2011·PLoS Pathogens·Yorifumi SatouMasao Matsuoka
Sep 27, 2013·PLoS Pathogens·Nanae Yamamoto-TaguchiMasao Matsuoka
May 7, 2009·Future Microbiology·Chloé JournoRenaud Mahieux
Oct 2, 2014·Virology Journal·Heather A NiedererCharles R M Bangham
Apr 24, 2010·Médecine sciences : M/S·Madeleine Duc DodonBenoit Barbeau
Dec 9, 2009·Expert Review of Anti-infective Therapy·Péter BagossiJózsef Tözsér
Feb 6, 2016·Viruses·Tiejun Zhao
Oct 26, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Kuan-Teh Jeang
Jul 6, 2010·Molecular Aspects of Medicine·Masao Matsuoka
Apr 23, 2013·Reviews in Medical Virology·Yorifumi Satou, Masao Matsuoka
Mar 17, 2016·Retrovirology·Guangyong MaMasao Matsuoka
Feb 1, 2015·La Revue de médecine interne·M LeclercqI Marie
Sep 26, 2013·Current Opinion in Virology·Masao Matsuoka, Jun-Ichirou Yasunaga
Nov 7, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Rafaela Gomes AndradeMarina Lobato Martins
Jun 21, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Natsumi ArayaYoshihisa Yamano
Oct 28, 2016·Journal of Medical Virology·Sayed-Hamidreza MozhganiMehdi Norouzi
Nov 16, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Anselmo SouzaEdgar Marcelino de Carvalho
Oct 15, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E RamirezM A Valenzuela
Dec 1, 2017·Journal of Clinical Medicine·Uyen Ngoc MuiStephen K Tyring
Oct 25, 2017·Wellcome Open Research·Martin R BillmanCharles R M Bangham
Jan 10, 2018·Frontiers in Microbiology·Yoshimi Enose-AkahataSteven Jacobson
Jan 10, 2018·Frontiers in Microbiology·Marco BaratellaRoberto S Accolla
Nov 30, 2012·Uirusu·Yorifumi Satou
Jul 19, 2019·Medical Microbiology and Immunology·Asadollah MohammadiHoushang Rafatpanah
Dec 25, 2010·Acta Microbiologica Et Immunologica Hungarica·Joseph G Sinkovics
Oct 24, 2014·Expert Review of Clinical Immunology·Fabiola MartinSteven Jacobson
Jan 1, 2019·Uirusu·Kosuke ToyodaMasao Matsuoka
Jan 31, 2018·Frontiers in Microbiology·Hélène GazonLuc Willems
Dec 1, 2019·Retrovirology·Yoshimi Enose-Akahata, Steven Jacobson
Mar 9, 2018·Frontiers in Microbiology·Stefania FochiMaria G Romanelli
Dec 22, 2012·Leukemia Research and Treatment·Aileen Rowan, Charles R M Bangham
Jun 18, 2020·Frontiers in Microbiology·Hiba El HajjOlivier Hermine
Apr 13, 2018·Frontiers in Microbiology·Sara MoodadHiba El Hajj
Oct 28, 2019·Viruses·Antonio Carlos Rosário VallinotoRicardo Ishak
May 21, 2019·Frontiers in Microbiology·Satoshi Nozuma, Steven Jacobson
Jul 13, 2016·Cancer Research·Kenji SugataMasao Matsuoka
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Amanda R PanfilKristine E Yoder

Methods Mentioned

BETA
transgenic
FCS
PCR

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