In vivo feasibility of image-guided transvaginal focused ultrasound therapy for the treatment of intracavitary fibroids

Fertility and Sterility
Arthur H ChanShahram Vaezy

Abstract

To determine the feasibility of uterine tissue ablation in vivo using a transvaginal focused ultrasound applicator guided by ultrasound imaging. Randomized in vivo animal study. Academic research environment. Healthy anesthetized sheep. Uterine treatment location was determined using a computerized targeting system. Five sonications 10 seconds in duration and averaging 2,000 W/cm(2) of focal ultrasound intensity were applied in each animal's uterus. Animals were euthanized either immediately or 2, 7, or 30 days post-treatment. Gross and microscopic analysis of the dissected uterus was used to quantitatively and qualitatively determine the ablated region and treatment side effects. Treatments resulted in coagulative necrosis. Histopathological analysis showed that over 7 days, inflammatory cells appeared and smooth muscle bundles regenerated. By day 30, treated tissues healed and scar tissue formed. None of the animals showed abnormal behavior or medical problems. Complications in three animals were damage to the vaginal wall and colon, possibly due to inadequate applicator cooling and an empty bladder during treatment. Transvaginal image-guided high-intensity focused ultrasound has potential for treating uterine fibroids. Furth...Continue Reading

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Citations

Oct 31, 2006·Annals of Biomedical Engineering·Jessica L FoleyShahram Vaezy
Aug 30, 2008·Srpski arhiv za celokupno lekarstvo·Milan Terzić
Sep 9, 2008·Journal of Minimally Invasive Gynecology·Tinghe YuJiao Zhang
Apr 4, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Sagi HarnofNeal F Kassel
Mar 15, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Robert Thomas HeldShahram Vaezy
Oct 11, 2005·Journal of Minimally Invasive Gynecology·Gary N Frishman, Marcus W Jurema
Jan 11, 2007·Journal of Biomedical Optics·Zahid YaqoobChanghuei Yang
Mar 27, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Wen LuoGuangbin He
Jun 30, 2016·Physics in Medicine and Biology·Jingfei LiuKatherine W Ferrara

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