Abstract
Several parameters affect clinical trials in photodynamic therapy and influence the therapeutic outcome. Beside drug dose, light dose, drug-light interval and other variables, the fluence rate is a parameter that can influence the therapeutic results. In this study we have evaluated the fluence rate effect with a second-generation photosensitizer, tetra(m-hydroxyphenyl)chlorin (mTHPC) using a 7,12-dimethylbenz(a)anthracene induced early squamous cell carcinoma of the Syrian hamster cheek pouch as a tumor model. Following injection of 0.5 mg/kg of mTHPC, irradiation tests were performed at two drug-light intervals, 4 and 8 days. Wavelength and light dose were adapted from those applied routinely in clinical trials. Irradiations at 652 nm were carried out with fluences ranging from 8 to 20 J/cm2 delivered at fluence rates of 15 and 150 mW/cm2. Similar tests were also performed at 514 nm with a fluence of 80 J/cm2 delivered at fluence rates ranging from 25 to 125 mW/cm2. At both wavelengths and drug-light intervals for a given fluence, the higher fluence rates resulted in less tissue damage in tumor and healthy mucosae. However, the lower fluence rates yielded slightly less therapeutic selectivity. This study confirms that the flu...Continue Reading
References
Nov 1, 1992·Chest·E S Edell, D A Cortese
Jan 1, 1992·Seminars in Roentgenology·D Chien, R R Edelman
Dec 1, 1991·British Journal of Cancer·H B RisM C Berenbaum
Dec 1, 1991·Journal of the American Academy of Dermatology·R A NeumannW Gebhart
Jun 1, 1991·Radiation Research·T H FosterR Hilf
May 16, 1990·Journal of the National Cancer Institute·Y P Chen, C A Squier
Aug 1, 1990·Photochemistry and Photobiology·B J TrombergM W Berns
Jun 1, 1989·Pathology, Research and Practice·J Hurlimann, D Gardiol
Jan 1, 1989·Lasers in Surgery and Medicine·M J van Gemert, A J Welch
Nov 1, 1986·British Journal of Cancer·M C BerenbaumU J Winfield
Jun 1, 1995·Cancer·D R BraichotteH E van den Bergh
Nov 1, 1994·British Journal of Cancer·W AlianS Svanberg
Dec 1, 1994·Archives of Otolaryngology--head & Neck Surgery·L A LofgrenB M Steinberg
Jun 15, 1994·International Journal of Cancer. Journal International Du Cancer·L MaK Berg
Dec 1, 1993·The Journal of Laryngology and Otology·W E GrantS G Bown
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FuruseC Konaka
Feb 1, 1996·International Journal of Experimental Pathology·S AndrejevicH van Den Bergh
Apr 1, 1954·Journal of Dental Research·J J SALLEY
May 1, 1955·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H A PADYKULA, E HERMAN
Dec 1, 1994·Physics in Medicine and Biology·M G Nichols, T H Foster
Citations
Jan 28, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C FrammeR Birngruber
Dec 2, 2000·Journal of Photochemistry and Photobiology. B, Biology·T GlanzmannG Wagnières
Sep 5, 2002·Journal of Photochemistry and Photobiology. B, Biology·S MurugesanO P D Noronha
Jun 26, 1998·Journal of Photochemistry and Photobiology. B, Biology·B W McIlroyA J MacRobert
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Jul 23, 2008·Photochemistry and Photobiology·Mukund Seshadri, David A Bellnier
Aug 20, 2010·Photochemistry and Photobiology·Lucia KulikováPeter Fedoročko
Aug 19, 2011·Photochemistry and Photobiology·Mathias O Senge, Johan C Brandt
Oct 1, 1997·Lasers in Medical Science·S A BlantP Monnier
Sep 16, 2000·Photochemistry and Photobiology·J P RoversM F Grahn
Sep 1, 2004·Photodiagnosis and Photodynamic Therapy·M AtifS B Brown
Feb 12, 2002·Photochemistry and Photobiology·Lars Kunz, Alexander J MacRobert
Nov 25, 2003·Photochemistry and Photobiology·François BorleGeorges Wagnières
Oct 25, 2000·Photochemistry and Photobiology·J Y ChenN H Cheung
Apr 3, 2001·Photochemistry and Photobiology·S CoutierF Guillemin
Dec 17, 2003·British Journal of Cancer·F BorleG Wagnières
Oct 28, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Boris Ya Kogan
Aug 15, 2002·Radiation Research·Stéphanie CoutierFrançois Guillemin
Jan 23, 2003·Radiation Research·Hugo SchouwinkFiona A Stewart
Apr 13, 2002·Photochemistry and Photobiology·Jarod C FinlayThomas H Foster
Jul 26, 2016·Biomedical Optics Express·Katja HaedickeIngrid Hilger
Mar 17, 1998·Archives of Biochemistry and Biophysics·F E DayanN J Jacobs
Jan 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F StewartW Star