PMID: 8605089Mar 1, 1996Paper

In vivo fluorescence kinetics and localisation of aluminum phthalocyanine disulphonate in an autologous tumour model

British Journal of Cancer
M J WitjesJ L Roodenburg

Abstract

Sulphonated phthalocyanines are studied as photosensitizers for photodynamic therapy of cancer. Their strong fluorescence and tumour-localising properties make them also potentially useful for detection of cancer by fluorescence. For this purpose, we have studied the fluorescence kinetics and localisation of aluminum phthalocyanine disulphonate (AlPcS2) in 4-nitroquinoline 1-oxide (4NQO)-induced dysplasia and invasive cancer of the oral mucosa of the hard palate in Wistar albino rats. Twenty-two rats were divided into six groups. Five groups were subjected to a 4NQO application period of 8, 12, 16, 20 or 26 weeks and one was a control group. The dysplasia varied from slight to severe and was correlated with the duration of the application period. All animals received a dose of 1 micromol/kg AlPcS2 i.v. Fluorescence images were recorded via a specially designed 'palatoscope' with excitation at 460 +/- 20 nm for autofluorescence, 610 +/- 15 nm for AlPcS2 fluorescence and detection of emission at 675 +/- 15 nm. After subtraction of the two images the specific AlPcS2 fluorescence remained. AlPcS2-mediated fluorescence increased significantly when the severity of dysplasia increased (P<0.04). Also the phenomenon of strong fluorescen...Continue Reading

Citations

Mar 18, 2015·Biomedical Optics Express·Amalina Bte Ebrahim AttiaMalini Olivo
Feb 24, 2001·Photochemistry and Photobiology·H J van StaverenW M Star
Jan 2, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nicolas Bézière, Vasilis Ntziachristos
Apr 5, 2012·The Journal of Physical Chemistry. a·Arkadiusz JarotaHalina Abramczyk
Aug 28, 2013·Bioconjugate Chemistry·Elena RanyukBrigitte Guérin

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