In Vivo genotoxicity of a commercial C.I. Disperse Red 1 dye

Environmental and Molecular Mutagenesis
Fábio Henrique FernandesDaisy Maria Fvero Salvadori

Abstract

Color Index (C.I.) Disperse Red 1 (DR1) is a widely used textile azo dye found in rivers. As it may not be completely removed by conventional treatments, humans can be exposed through drinking water. Studies have supported in vitro toxicity and mutagenicity of commercial DR1. This study aimed to investigate the mutagenic and toxicogenomic effects of commercial DR1 in multiple tissues/organs of Swiss male mice. For that, animals were orally exposed to the dye (by gavage), at single doses of 0.0005, 0.005, 0.5, 50, or 500 mg/kg bw. The two lowest doses were equivalent to the ones found in two Brazilian rivers receiving influx of textile discharges. Cytotoxicity, micronucleated cell frequencies (for all doses tested), primary DNA damage (comet assay), and gene expression profiling of (0.0005 and 0.005 mg/kg of bw) were investigated 24 hr after animal exposure to commercial DR1. Data showed increased frequencies of micronucleated polychromatic erythrocytes in bone marrow cells after treatment with 0.5 and 50 mg/kg bw. At 0.005 mg/kg bw, commercial DR1 induced an increase of primary DNA damage in liver, but not in kidney cells. Additionally, upregulation of genes involved in the inflammatory process (IL1B) (0.0005 and 0.005 mg/kg bw...Continue Reading

References

Sep 1, 1992·Mutation Research·K T Chung, C E Cerniglia
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Dec 31, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F RafiiC E Cerniglia
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Dec 13, 2000·Mutation Research·G Krishna, M Hayashi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 22, 2003·Toxicology Letters·Hongli LiShixiang Peng
May 25, 2005·Chemosphere·Gisela de Aragão UmbuzeiroLarry D Claxton
May 16, 2009·Mutation Research·Farah Maria Drumond ChequerDanielle Palma de Oliveira
Oct 27, 2009·Journal of Hazardous Materials·Patricia A CarneiroMaria Valnice B Zanoni
Sep 13, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Farah Maria Drumond ChequerDanielle Palma de Oliveira
Dec 8, 2011·Methods in Molecular Biology·Brian Burlinson
Nov 28, 2012·The Science of the Total Environment·Francine Inforçato VacchiGisela Umbuzeiro
Feb 1, 2015·Journal of Chromatographic Science·Guilherme Julião ZocoloMaria Valnice Boldrin Zanoni
Apr 18, 2015·Reproductive Toxicology·Fábio Henrique FernandesDaisy Maria Fávero Salvadori
Jul 15, 2015·Environmental Health Perspectives·Nehme El-HachemBenjamin Haibe-Kains
May 14, 2016·Chemosphere·Francine Inforçato VacchiGisela de Aragão Umbuzeiro
Jul 15, 2016·Environmental and Molecular Mutagenesis·Francine I VacchiGisela A Umbuzeiro
May 30, 2017·The Science of the Total Environment·Francine Inforçato VacchiGisela de Aragão Umbuzeiro
Jan 13, 2018·Mutagenesis·Peter Møller

❮ Previous
Next ❯

Citations

Jan 1, 2019·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Fábio Henrique FernandesDaisy Maria Fávero Salvadori
Aug 31, 2021·Environmental and Molecular Mutagenesis·Amanda Rodrigues TanamachiDaisy Maria Fávero Salvadori

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ivani AquinoE L Maistro
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A M Api
© 2022 Meta ULC. All rights reserved