In vivo gradients of thalamic damage in paediatric multiple sclerosis: a window into pathology.

Brain : a Journal of Neurology
Ermelinda De MeoMaria A Rocca

Abstract

The thalamus represents one of the first structures affected by neurodegenerative processes in multiple sclerosis. A greater thalamic volume reduction over time, on its CSF side, has been described in paediatric multiple sclerosis patients. However, its determinants and the underlying pathological changes, likely occurring before this phenomenon becomes measurable, have never been explored. Using a multiparametric magnetic resonance approach, we quantified, in vivo, the different processes that can involve the thalamus in terms of focal lesions, microstructural damage and atrophy in paediatric multiple sclerosis patients and their distribution according to the distance from CSF/thalamus interface and thalamus/white matter interface. In 70 paediatric multiple sclerosis patients and 26 age- and sex-matched healthy controls, we tested for differences in thalamic volume and quantitative MRI metrics-including fractional anisotropy, mean diffusivity and T1/T2-weighted ratio-in the whole thalamus and in thalamic white matter, globally and within concentric bands originating from CSF/thalamus interface. In paediatric multiple sclerosis patients, the relationship of thalamic abnormalities with cortical thickness and white matter lesions...Continue Reading

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Apr 10, 2010·IEEE Transactions on Medical Imaging·Nicholas J TustisonJames C Gee
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardClaudia A M Wheeler-Kingshott
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Mar 12, 2011·AJNR. American Journal of Neuroradiology·S MesarosM Filippi
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew F Glasser, David C Van Essen
Aug 16, 2011·Brain : a Journal of Neurology·Owain W HowellRichard Reynolds
Dec 14, 2011·Annals of Neurology·Natalia M MollElizabeth Fisher
Mar 31, 2012·Journal of Neuroimmunology·Robert P LisakAmit Bar-Or
Oct 16, 2012·Brain : a Journal of Neurology·James KolasinskiHeidi Johansen-Berg
Mar 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Ralph Hb BenedictRobert Zivadinov
Apr 10, 2013·NeuroImage·Matthew F GlasserDavid C Van Essen
Apr 11, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Lauren B KruppUNKNOWN International Pediatric Multiple Sclerosis Study Group
Oct 15, 2013·Neurology·Massimo FilippiMaria A Rocca
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Håkon GrydelandAnders M Fjell
Jan 16, 2014·Journal of the Neurological Sciences·Roberto CappellaniRobert Zivadinov
Apr 29, 2014·Translational Oncology·Thomas L ChenevertBrian D Ross
Jun 5, 2014·Brain : a Journal of Neurology·Oscar G VidaurrePatrizia Casaccia
Jun 6, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Lukas HaiderJosa M Frischer
Sep 18, 2014·Frontiers in Human Neuroscience·Marco GanzettiDante Mantini
Nov 8, 2014·Neurology·Bérengère Aubert-BrocheUNKNOWN Canadian Pediatric Demyelinating Disease Network
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Markus KippOmid Nikoubashman
Feb 15, 2015·Brain : a Journal of Neurology·Caterina MaineroRevere P Kinkel
Jun 19, 2015·Annals of Neurology·Margit JehnaChristian Enzinger
Jul 21, 2016·Nature·Matthew F GlasserDavid C Van Essen
Sep 8, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Matteo PardiniDeclan T Chard
Oct 26, 2016·Annals of Neurology·Elena HerranzCaterina Mainero
Dec 18, 2016·Neurology·Maria A RoccaMassimo Filippi
Dec 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jennifer E SounJack Grinband
Jan 4, 2017·Brain : a Journal of Neurology·J William L BrownDeclan T Chard
Aug 15, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Céline LouapreCaterina Mainero

❮ Previous
Next ❯

Citations

Apr 4, 2021·Brain Sciences·Emilio PortaccioMaria Pia Amato
Aug 12, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Albulena BajramiMassimiliano Calabrese

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.