In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill.

Journal of Natural Medicines
M L GonzagaLetícia Veras Costa-Lotufo

Abstract

Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different parts of the world due to its anticancer potential. This effect is generally attributed to its polysaccharides; however, the precise structure of these has not been fully characterized. To better understand the relationship between polysaccharide structures and antitumor activity, we investigated the effect of the intraperitoneally (i.p.) or orally (p.o.) administered alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide from A. blazei alone or in association with 5-fluorouracil (5-FU) in tumor growth using Sarcoma 180 transplanted mice. Hematological, biochemical, and histopathological analyses were performed in order to evaluate the toxicological aspects of the polysaccharide treatment. The polysaccharide had no direct cytotoxic action on tumor cells in vitro. However, the polysaccharide showed strong in vivo antitumor effect. Thus, the tumor growth-inhibitory effect of the polysaccharide is apparently due to host-mediated mechanisms. The histopathological analysis suggests that the liver and the kidney were not affected by polysaccharide treatment. Neither enzymatic activity of transaminases (AST and ALT) nor urea le...Continue Reading

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Citations

Nov 26, 2010·Journal of Medicinal Food·Júlia GyörfiJános Vetter
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hang WangChunchao Han
Dec 10, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Veronica FerrucciMassimo Zollo
Sep 5, 2012·Carbohydrate Polymers·Aizhen ZongFengshan Wang
Apr 1, 2012·Saudi Journal of Biological Sciences·Komsit WisitrassameewongKevin D Hyde
May 3, 2014·Journal of Ethnopharmacology·Ulrike GrienkeJudith M Rollinger
Jan 24, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C E P ZimmermannJ M Santurio
Jul 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Grace Anne A DóriaAdriano A S Araujo
May 5, 2018·Natural Product Research·Urja PandyaNirmal S Sahay
Jan 21, 2017·Current Pharmaceutical Design·Aline Cristine da Silva de SouzaRosane Marina Peralta
Sep 10, 2013·Chemico-biological Interactions·Maria A Carvalho RodriguesAntonio Cardozo dos Santos

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