In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice.

Malaria Research and Treatment
Rosangela FritaThomas Hänscheid

Abstract

Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle. This free Hz is ingested by circulating and resident phagocytes. The presence of Hz in tissues after clearance of infection has been previously reported. Still, little is known about the kinetics of Hz in vivo, during and after Plasmodium infection. It is particularly important to understand Hz kinetics after malaria infections as it has been reported that Hz is associated with impairment of immune functions, including possible consequences for coinfections. Indeed, if Hz remains biologically active for prolonged periods of time inside immunocompetent cells, the potential consequences of such accumulation and presence to the immune system should be clarified. Here, using several independent methods to assess the presence of Hz, we report the long-term in vivo kinetics of Hz in diverse organs in a murine model of malaria infection.

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Citations

Dec 15, 2015·FEMS Microbiology Reviews·Katrien DeroostPhilippe E Van den Steen
Aug 3, 2013·BioFactors·Ariane TybergheinPhilippe E Van den Steen
Feb 11, 2015·Cell Biochemistry and Function·Alexandra C Schrimpe-RutledgeDavid W Wright
Jan 7, 2014·British Journal of Haematology·Ruth AguilarClara Menéndez
Feb 22, 2014·Biochimica Et Biophysica Acta·Lorena M CoronadoCarmenza Spadafora
Aug 8, 2017·Science Immunology·Michelle S J LeeCevayir Coban
Jul 10, 2013·Current Protocols in Cytometry·Howard M ShapiroBrian T Grimberg
Dec 17, 2019·Immunological Reviews·Katherine R DobbsArlene E Dent
Jul 28, 2020·Frontiers in Cellular and Infection Microbiology·Christopher L HardingNathan W Schmidt
Mar 19, 2016·Journal of Toxicologic Pathology·Etsuko OhtaSatoru Hosokawa
Oct 7, 2017·Frontiers in Cellular and Infection Microbiology·Janaiara A CunhaCláudio Tadeu Daniel-Ribeiro
Jan 20, 2021·Journal of Leukocyte Biology·Debopam Ghosh, Jason S Stumhofer
Nov 24, 2020·Trends in Parasitology·Thao-Thy PhamPhilippe E Van den Steen

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Methods Mentioned

BETA
flow cytometry
depolarization

Software Mentioned

Image J

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