PMID: 9435614Jan 22, 1998Paper

In vivo hydraulic conductivity of muscle: effects of hydrostatic pressure

The American Journal of Physiology
Zakaria el-RM F Flessner

Abstract

We and others have shown that the loss of fluid and macromolecules from the peritoneal cavity is directly dependent on intraperitoneal hydrostatic pressure (Pip). Measurements of the interstitial pressure gradient in the abdominal wall demonstrated minimal change when Pip was increased from 0 to 8 mmHg. Because flow through tissue is governed by both interstitial pressure gradient and hydraulic conductivity (K), we hypothesized that K of these tissues varies with Pip. To test this hypothesis, we dialyzed rats with Krebs-Ringer solution at constant Pip of 0.7, 1.5, 2.2, 3, 4.4, 6, or 8 mmHg. Tracer amounts of 125I-labeled immunoglobulin G were added to the dialysis fluid as a marker of fluid movement into the abdominal wall. Tracer deposition was corrected for adsorption to the tissue surface and for local loss into lymphatics. The hydrostatic pressure gradient in the wall was measured using a micropipette and a servo-null system. The technique requires immobilization of the tissue by a porous Plexiglas plate, and therefore a portion of the tissue is supported. In agreement with previous results, fluid flux into the unrestrained abdominal wall was directly related to the overall hydrostatic pressure difference across the abdomin...Continue Reading

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Citations

Feb 5, 2005·American Journal of Physiology. Renal Physiology·Michael F Flessner
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·J Stachowska-PietkaB Lindholm
Mar 29, 2019·Biomechanics and Modeling in Mechanobiology·Iftah NudelGal deBotton
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S McGuire, F Yuan
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M F Flessner
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·X Y ZhangF Yuan
Mar 16, 2006·Lasers in Surgery and Medicine·Lise Lyngsnes RandebergLars O Svaasand
Mar 31, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jacek WaniewskiMichael F Flessner
Jun 3, 2000·American Journal of Physiology. Renal Physiology·E R ZakariaM F Flessner
Aug 25, 2005·American Journal of Physiology. Renal Physiology·Michael F FlessnerMichael Hughson
Apr 27, 2007·Annual Review of Biomedical Engineering·Melody A Swartz, Mark E Fleury
Oct 21, 2016·Mathematical Medicine and Biology : a Journal of the IMA·Iftah NudelGal deBotton
Nov 16, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mario CabodiAbraham D Stroock

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