In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation

Theranostics
Bastian ZinnhardtAndreas H Jacobs

Abstract

Modulation of the inflammatory microenvironment after stroke opens a new avenue for the development of novel neurorestorative therapies in stroke. Understanding the spatio-temporal profile of (neuro-)inflammatory imaging biomarkers in detail thereby represents a crucial factor in the development and application of immunomodulatory therapies. The early integration of quantitative molecular imaging biomarkers in stroke drug development may provide key information about (i) early diagnosis and follow-up, (ii) spatio-temporal drug-target engagement (pharmacodynamic biomarker), (iii) differentiation of responders and non-responders in the patient cohort (inclusion/exclusion criteria; predictive biomarkers), and (iv) the mechanism of action. The use of targeted imaging biomarkers for may thus allow clinicians to decipher the profile of patient-specific inflammatory activity and the development of patient-tailored strategies for immunomodulatory and neuro-restorative therapies in stroke. Here, we highlight the recent developments in preclinical and clinical molecular imaging biomarkers of neuroinflammation (endothelial markers, microglia, MMPs, cell labeling, future developments) in stroke and outline how imaging biomarkers can be use...Continue Reading

Citations

Apr 2, 2019·Stroke; a Journal of Cerebral Circulation·Thomas BonnardDenis Vivien
May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Honglei RenJian Wang
Jun 20, 2019·Frontiers in Immunology·Franziska M CollmannMathias Hoehn
Jan 22, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Philipp BackhausJens Minnerup
Apr 4, 2021·Antioxidants·Eduardo Felipe Alves Fernandes, Dennis Özcelik
Jun 3, 2021·Pharmaceutics·Clara Correa-PazFrancisco Campos
Oct 14, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ruiqing NiLinjing Mu

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Methods Mentioned

BETA
imaging techniques
chemical exchange saturation transfer
biopsies

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