In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
Maarten TruijersJan D Blankensteijn

Abstract

To study the potential of integrated positron emission tomography and computed tomography (PET/CT) to identify aneurysm wall inflammation. The level of F18-fluorodeoxyglucose (FDG) uptake was studied in aneurysmal and normal-sized aortas of 34 male patients [17 with abdominal aortic aneurysm (AAA) and 17 age-matched controls] identified in a database of 278 consecutive patients evaluated for staging of primary lung cancer. The maximal standardized uptake value (SUV) was calculated to quantify FDG uptake in the AAA wall. AAAs showed significantly higher FDG uptake than the normal-sized aorta in age-matched controls (SUV 2.52+/-0.52 versus 1.78+/-0.45, respectively; p<0.001). The level of FDG uptake did not correlate with maximal aneurysm diameter (r=0.09; 95% CI -0.42 to 0.56; p=0.7). FDG-PET/CT is a promising technique to identify inflammation of the aneurysm wall. Irrespective of aneurysm diameter, asymptomatic AAAs show more FDG uptake and more inflammatory activity in the wall than the non-dilated abdominal aorta of sex/age-matched controls. Future studies will be directed at the predictive value of increased FDG uptake for aneurysm wall strength, rupture risk, and the utility of FDG-PET/CT in assessing the effect of medical...Continue Reading

References

Nov 11, 1998·Journal of Vascular Surgery·S C NichollsH K Johansen
May 4, 2000·The American Journal of Pathology·J H YangR T Lee
May 25, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N SakalihasanR Limet
Jun 18, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Tarik BelhocineLuc Mortelmans
Aug 30, 2003·Journal of Vascular Surgery·Gorav AilawadiGilbert R Upchurch
Oct 11, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Chantal P Bleeker-RoversWim J G Oyen
Mar 11, 2004·Experimental and Molecular Pathology·Eiketsu ShoRonald L Dalman
Jun 9, 2004·Seminars in Vascular Surgery·Natzi SakalihasanRaymond Limet
Aug 24, 2004·Current Vascular Pharmacology·Keiji YamamotoKazuyuki Shimada
May 17, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E ChokeM M Thompson
Dec 21, 2005·European Radiology·Sandra J RosenbaumAndreas Bockisch
Mar 8, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·O SchoutenD Poldermans
Nov 7, 2006·Journal of the American College of Cardiology·Nobuhiro TaharaTsutomu Imaizumi
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Simona Ben-HaimOra Israel
Oct 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gonca G BuralAbass Alavi
Oct 31, 2007·The British Journal of Surgery·S AbisiA Smith

❮ Previous
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Citations

Apr 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Carl W KotzeSyed W Yusuf
Oct 21, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Cecilia MariniGianmario Sambuceti
May 31, 2012·The International Journal of Cardiovascular Imaging·Benoit DesjardinsUNKNOWN American College of Radiology
Nov 3, 2010·Cardiovascular Research·Jean-Baptiste MichelUNKNOWN FAD EU consortium
Mar 24, 2011·AJR. American Journal of Roentgenology·Michael K AtalayKevin J Chang
Oct 29, 2009·The American Journal of Tropical Medicine and Hygiene·Cibele M PradoLinda A Jelicks
Jan 2, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Reza Golestani, Mehran M Sadeghi
Aug 27, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Tara D BarwickM J O'Doherty
Aug 28, 2013·The International Journal of Cardiovascular Imaging·Frederik F StroblTobias Saam
Feb 16, 2010·Cellular and Molecular Life Sciences : CMLS·Caspar Grond-GinsbachMarie-Luise Gross-Weissmann
May 21, 2015·International Journal of Molecular Sciences·Jenny B LinCraig J Goergen
Sep 3, 2013·Progress in Cardiovascular Diseases·Katherine H Chau, John A Elefteriades
Feb 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·John A ElefteriadesGregory A Kuzmik
Dec 1, 2010·The Journal of Thoracic and Cardiovascular Surgery·John A Elefteriades
Apr 1, 2012·International Journal for Numerical Methods in Biomedical Engineering·Andreas MaierChristian Reeps
Feb 28, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·O M B McBrideS I Semple
Apr 28, 2009·Journal of Vascular Surgery·Maarten TruijersJan D Blankensteijn
Feb 27, 2010·Journal of the American College of Cardiology·John A Elefteriades, Emily A Farkas
May 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Myriam AmsallemMichael V McConnell
Sep 1, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Jip L TolenaarJean-Paul P M de Vries
Feb 10, 2011·Nature Reviews. Cardiology·Ahmed KlinkZahi A Fayad
Apr 14, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Toshihiro TsurudaKazuo Kitamura
Jan 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthias NahrendorfRalph Weissleder
Jan 1, 2015·Circulation. Cardiovascular Imaging·Reza GolestaniMehran M Sadeghi
Jan 15, 2016·Circulation. Cardiovascular Imaging·Jakub ToczekMehran M Sadeghi
Jul 23, 2009·Current Opinion in Cardiology·Jonathan Golledge, Paul E Norman
Mar 16, 2019·Circulation. Cardiovascular Imaging·Rachael O Forsythe, David E Newby
Jul 1, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Allan W ReidGiles H Roditi
Jul 27, 2010·The Open Cardiovascular Medicine Journal·Kosmas I ParaskevasDimitri P Mikhailidis
Sep 14, 2013·Current Opinion in Cardiology·Michael D Hope, Thomas A Hope
Apr 17, 2020·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Erik Groot JebbinkMichel M P J Reijnen
Mar 30, 2017·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Robert DrescherMartin Freesmeyer
Nov 14, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mercy I AkereleCharalampos Tsoumpas
Sep 25, 2019·International Journal of Molecular Sciences·Matthew J KellyDai Yamanouchi

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