In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

Organic & Biomolecular Chemistry
Ayumi TsutsuiKatsunori Tanaka


Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and the development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and various disorders associated with them, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders.


Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YokoiK Usui
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Mar 29, 2001·Diabetologia·R SinghL Beilin
Jul 12, 2002·Diabetes/metabolism Research and Reviews·Feng ZhengHelen Vlassara
Apr 2, 2004·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Makoto NaitoTakashi Yamamoto
Oct 19, 2006·Nuclear Medicine and Biology·Christina HultschThomas Henle
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jaime UribarriHelen Vlassara
Apr 23, 2008·Chemical Reviews·Simon M AmetameyPius August Schubiger
May 14, 2008·Current Pharmaceutical Design·Hideyuki Hyogo, Sho-ichi Yamagishi
Oct 27, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Richard D SembaLuigi Ferrucci
Jan 5, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Marta PiroddiFrancesco Galli
Jul 7, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Kazumi Kita
Nov 9, 2014·In Vitro Cellular & Developmental Biology. Animal·Xu WangLi-De Zhang

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