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In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

Nature Medicine

Apr 12, 2005

Martin KerschensteinerThomas Misgeld

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Abstract

The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury. Here, we monitor individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury. We find that within 30 min after trauma, axons...read more

Mentioned in this Paper

Post-Traumatic Myelopathy
Calpain II
Pathogenic Aspects
Abnormal Degeneration
Pathogenesis
Malignant Neoplasm of Spinal Cord
Time-Lapse Imaging
Nerve Degeneration
Immunofluorescence Microscopy
House mice
376
1
1
Paper Details
References
  • References19
  • Citations238
12
  • References19
  • Citations238
12345...

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Spinal Cord Neoplasms

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Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord

Proceedings of the National Academy of Sciences of the United States of AmericaMay 28, 2009
Cyril DrayFranck Debarbieux
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In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

Nature Medicine

Apr 12, 2005

Martin KerschensteinerThomas Misgeld

PMID: 15821747

DOI: 10.1038/nm1229

Abstract

The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury. Here, we monitor individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury. We find that within 30 min after trauma, axons...read more

Mentioned in this Paper

Post-Traumatic Myelopathy
Calpain II
Pathogenic Aspects
Abnormal Degeneration
Pathogenesis
Malignant Neoplasm of Spinal Cord
Time-Lapse Imaging
Nerve Degeneration
Immunofluorescence Microscopy
House mice
376
1
1

Feeds With Similar Papers

Wallerian Degeneration

Wallerian Degeneration refers to active degeneration of part of the axon distal to the injury in response to nerve fiber damage. Here is the latest research on aspects underlying this degeneration

Organ Regeneration

Regeneration in humans is the regrowth of tissues or organs in response to injury or damage. Discover the latest research on organ neuroregeneration here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord

Proceedings of the National Academy of Sciences of the United States of AmericaMay 28, 2009
Cyril DrayFranck Debarbieux
Paper Details
References
  • References19
  • Citations238
12
  • References19
  • Citations238
12345...

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Publisher
PubMed
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