In vivo imaging of axonal transport using MRI: aging and Alzheimer's disease

European Journal of Nuclear Medicine and Molecular Imaging
Satoshi Minoshima, Donna J Cross

Abstract

MRI using manganese as a trans-synaptic axonal tracing agent can unveil dynamics of axonal transport in living subjects. We use this technology to test the hypotheses if impaired axonal transport is a significant pathophysiological process in aging and early Alzheimer's disease (AD) and in part accounting for "selective vulnerability" of projection neurons in AD. To allow quantitative assessment of axonal transport in vivo, we developed voxel-based statistical mapping technology as well as a tracer kinetic modeling method based on mass transport for manganese-enhanced MRI to estimate axonal transport rates in aging rats and AD transgenic mice. These techniques demonstrated manganese-enhanced signal changes in axonal projections of the olfactory tract and decreased axonal transport rates in rodent models of aging and AD. Altered axonal transport may be a critical pathophysiological process in aging and AD. Manganese-enhanced MRI provides exciting opportunities for the investigations of altered axonal transport in AD and related disorders.

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Citations

Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael B SteketeeJeffrey L Goldberg
Aug 13, 2008·Human Molecular Genetics·Gorazd B StokinLawrence S B Goldstein
Feb 4, 2010·PLoS Biology·Jonathan Gilley, Michael P Coleman
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Nov 2, 2019·Traffic·Sunaina SuranaGiampietro Schiavo
Feb 5, 2021·NMR in Biomedicine·Emily PetrusAlan P Koretsky
Jun 28, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Donna J CrossSatoshi Minoshima
Jul 27, 2021·Journal of Alzheimer's Disease : JAD·Donna J CrossSatoshi Minoshima

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