In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy

Biomedical Optics Express
Cristina CanavesiHolly B Hindman

Abstract

Gabor-domain optical coherence microscopy (GDOCM) demonstrated in vivo corneal imaging with cellular resolution and differentiation in mice over a field of view of 1 mm2. Contact and non-contact imaging was conducted on six healthy and six hyperglycemic C57BL/6J mice. Cellular resolution in the 3D GDOCM images was achieved after motion correction. Corneal nerve fibers were traced and their lengths and branches calculated. Noncontact, label-free imaging of corneal nerves has clinical utility in health and disease, and in transplant evaluation. To the authors' knowledge, this is the first report of in vivo 3D corneal imaging in mice with the capability to resolve nerve fibers using a non-contact imaging modality.

References

Nov 22, 1991·Science·D HuangC A Puliafito
Jan 1, 1984·Survey of Ophthalmology·J H KrachmerM W Belin
May 3, 2001·Cornea·L Oliveira-Soto, N Efron
Feb 27, 2004·Cell Biology International·Shaun P Collin, H Barry Collin
Sep 29, 2004·Diabetes Care·Donald S FongRonald Klein
May 26, 2005·Investigative Ophthalmology & Visual Science·Alistair J BarberSarah K Bronson
Jul 15, 2005·Cornea·Jay C ErieWilliam M Bourne
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Dipika V Patel, Charles N J McGhee
Aug 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Oliver StachsRudolf Guthoff
Feb 24, 2007·American Journal of Ophthalmology·Biljana MiljanovićDebra A Schaumberg
Jul 13, 2007·Ophthalmology·J Bradley RandlemanR Doyle Stulting
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·P ThévenazM Unser
Jan 17, 2009·Optics Letters·Supraja MuraliJannick P Rolland
Aug 19, 2009·Clinical Ophthalmology·Johnny L Gayton
Dec 29, 2009·Experimental Eye Research·Carl F MarfurtLauren Dvorscak
Apr 15, 2010·Optics Express·Jannick P RollandKye-sung Lee
May 22, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Elisabeth M MessmerAnselm Kampik
Jun 12, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Miguel Romero-JiménezJames S Wolffsohn
Mar 31, 2011·Investigative Ophthalmology & Visual Science·Stephan AllgeierOliver Stachs
Jul 28, 2011·Investigative Ophthalmology & Visual Science·David C MuschAlan Sugar
Mar 5, 2013·Survey of Ophthalmology·Dipika V Patel, Charles N McGhee
Jan 28, 2014·Survey of Ophthalmology·Brittany Simmons ShaheenSandeep Jain
Aug 8, 2014·The American Journal of Pathology·Daniel CaiDanielle M Robertson
Oct 15, 2014·Experimental Animals·Atsushi TsukamotoTomo Inomata
Nov 19, 2014·Journal of the Peripheral Nervous System : JPNS·Matthew S YorekMark A Yorek
Jul 3, 2015·Journal of Diabetes Research·F SemeraroC Costagliola
Sep 9, 2015·JAMA : the Journal of the American Medical Association·David M Nathan
Oct 27, 2015·The British Journal of Ophthalmology·David L DeMillRoni M Shtein
Dec 4, 2015·JAMA Ophthalmology·Philippe GainGilles Thuret
Apr 14, 2016·Vision Research·Hee-Kyoung KoMartina Poletti
Apr 28, 2016·BioMed Research International·Victoria J Vieira-PotterDarren J Lee
May 5, 2016·Clinical Ophthalmology·Marcony R SanthiagoSamir J Bechara
Oct 25, 2016·The Ocular Surface·Andrea CruzatPedram Hamrah
Mar 9, 2017·Biomedical Optics Express·René M WerkmeisterLeopold Schmetterer
Jul 26, 2017·Acta Ophthalmologica·Joanna KokotEdward Wylęgała

❮ Previous
Next ❯

Citations

Jul 9, 2020·Biomedical Optics Express·Timothy D Weber, Jerome Mertz
Nov 6, 2020·Biomedical Optics Express·Sebastian BohnOliver Stachs
Mar 11, 2021·Applied Optics·Panomsak MeemonJoewono Widjaja
Feb 16, 2021·Journal of Lower Genital Tract Disease·Tamera PaczosRachel O'Connell
May 18, 2021·Biomedical Optics Express·Wei WeiCristina Canavesi
Nov 16, 2021·Translational Vision Science & Technology·Merle S SchenkStefan Kassumeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.