In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography

Biomedical Optics Express
Kevin S K WongMarinko V Sarunic

Abstract

Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo high-resolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing a clinical high-resolution retinal imaging system as it enables the use of a compact, low-cost and robust lens-based adaptive optics design. In this report, we describe our WSAO-OCT system for imaging the human photoreceptor mosaic in vivo. We validated our system performance by imaging the retina at several eccentricities, and demonstrated the improvement in photoreceptor visibility with WSAO compensation.

References

Nov 14, 1997·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·J LiangD T Miller
Aug 8, 2001·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·J PorterD R Williams
Jun 25, 2002·Vision Research·José Francisco Castejón-MochónPablo Artal
May 27, 2006·Optics Letters·Michael PircherChristoph K Hitzenberger
Dec 2, 2006·Journal of Cataract and Refractive Surgery·Thomas O Salmon, Corina van de Pol
Dec 15, 2006·Optics Letters·Martin J Booth
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Diana C ChenScot S Olivier
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Robert J ZawadzkiJohn S Werner
May 23, 2008·Progress in Retinal and Eye Research·Adrian Gh Podoleanu, Richard B Rosen
May 24, 2008·Vision Research·Joseph CarrollDavid R Williams
Jun 26, 2008·Optics Express·Delphine DébarreTony Wilson
Mar 5, 2009·Optics Express·Tilman SchmollRainer A Leitgeb
Dec 10, 2007·Optics Express·Michael PircherChristoph K Hitzenberger
Nov 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pooja GodaraJoseph Carroll
May 21, 2011·Vision Research·David R Williams
Jun 24, 2011·Biomedical Optics Express·Alfredo Dubra, Yusufu Sulai
Sep 22, 2011·Optics Express·Heidi HoferJason Porter
Jan 19, 2012·Biomedical Optics Express·Ravi S JonnalDonald T Miller
May 11, 2012·Biomedical Optics Express·Ying GengDavid R Williams
Oct 6, 2012·Optics Express·Franz FelbererMichael Pircher
May 7, 2013·Journal of Biomedical Optics·Yifan JianMarinko V Sarunic
Oct 25, 2013·Biomedical Optics Express·Thomas KleinRobert Huber
Feb 28, 2014·Biomedical Optics Express·Franz FelbererMichael Pircher
Feb 28, 2014·Biomedical Optics Express·Yifan JianMarinko V Sarunic
Jun 8, 2014·Investigative Ophthalmology & Visual Science·Drew ScolesAlfredo Dubra
Jul 30, 2014·Biomedical Optics Express·Omer P KocaogluDonald T Miller
Aug 20, 2014·Biomedical Optics Express·Xiaolin ZhouAndrew Metha
Jan 13, 2015·Biomedical Optics Express·Omer P KocaogluDonald T Miller

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Citations

Sep 15, 2015·Optics Express·Yongxin YuYuhua Zhang
Jan 29, 2016·Biomedical Optics Express·Daniel J WahlMarinko V Sarunic
Sep 30, 2015·Biomedical Optics Express·Xiaolin ZhouAndrew Metha
Jul 23, 2016·Biomedical Optics Express·Nathan S AlexanderKrzysztof Palczewski
Sep 8, 2016·Scientific Reports·Michelle CuaMarinko V Sarunic
Feb 15, 2017·Journal of Biomedical Optics·Maddipatla ReddikumarBarry Cense
Sep 23, 2016·Journal of Biomedical Optics·Peng XiaoAlbert Claude Boccara
Feb 18, 2016·Journal of Biomedical Optics·Michelle CuaMarinko V Sarunic
Nov 3, 2017·Journal of Biomedical Optics·Myeong Jin JuMarinko V Sarunic
Jun 10, 2016·Scientific Reports·Yifan JianMarinko V Sarunic
Sep 2, 2020·Optics Letters·Kristen HaganSina Farsiu
Sep 20, 2018·Optica·Theodore DuBoseSina Farsiu
Jul 25, 2017·Biomedical Optics Express·Hans R G W VerstraeteMarinko V Sarunic
Oct 16, 2018·Optics Letters·Myeong Jin JuMarinko V Sarunic
Jul 1, 2017·Biomedical Optics Express·Michael Pircher, Robert J Zawadzki
Feb 15, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J L ReinigerW M Harmening
Apr 1, 2017·Optics Letters·Daniel J WahlMarinko V Sarunic
Jul 1, 2017·Biomedical Optics Express·Yuan-Zhi LiuStephen A Boppart
Jul 6, 2021·Biomedical Optics Express·Shuibin NiYifan Jian

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