PMID: 6979042Jan 1, 1982Paper

In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch

Proceedings of the National Academy of Sciences of the United States of America
H KiyonoW J Koopman

Abstract

The first line of defense against pathogens that enter the host by the oral route appears to involve the gut-associated lymphoreticular tissue-e.g., Peyer's patches (PP). Although animals can readily be immunized by orally administered antigen that mobilizes the secretory immune system, there is a total lack of local antibody synthesis in the PP and the cellular basis for this deficiency remains a mystery. A lymphoreticular cell population, obtained when murine PP were treated with a neutral protease (Dispase), consisted of accessory cells [macrophages (MPhi)] and T and B lymphocytes. In vitro cultures of these PP cell preparations with the thymic-dependent antigen sheep erythrocytes (SRBC) resulted in good anti-SRBC plaque-forming cell (PFC) responses. The time courses of these responses were identical to those seen with spleen cell cultures. Submitogenic concentrations of concanavalin A (Con A) and optimal doses of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and lipopolysaccharide (LPS) enhanced in vitro responses of PP cell cultures to SRBC. PP possess fully functional antigen-presenting MPhi because incubation of optimal proportions of splenic T and B cells with purified populations of PP MPhi supported good in vitro immu...Continue Reading

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Citations

Jan 1, 1988·Immunologic Research·H KiyonoJ R McGhee
Jan 1, 1982·Journal of Immunological Methods·M V FrangakisJ R McGhee
Jun 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J J PestkaR L Warner
Feb 1, 1983·The Journal of Experimental Medicine·J H EldridgeJ R McGhee
May 1, 1983·The Journal of Experimental Medicine·D M SpaldingR M Steinman
Sep 1, 1984·The Journal of Experimental Medicine·D M SpaldingJ R McGhee
Jan 1, 1988·Acta Pathologica Japonica·S Kawaguchi
Jan 1, 1997·Springer Seminars in Immunopathology·K FujihashiJ R McGhee
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Jan 17, 2002·Archives of Pharmacal Research·J H KimW H Woo
Sep 1, 1988·Clinical Immunology and Immunopathology·S KawaguchiY Masugi
Jun 30, 1983·Annals of the New York Academy of Sciences·S M MichalekW J Koopman
Jun 30, 1983·Annals of the New York Academy of Sciences·R J GencoR T Evans
Jan 27, 2017·Annual Review of Immunology·Yosuke Kurashima, Hiroshi Kiyono
Mar 1, 1986·Scandinavian Journal of Immunology·U I DahlgrenL A Hanson
Dec 1, 1982·Scandinavian Journal of Immunology·H KiyonoJ R McGhee
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Dec 3, 2014·Vaccine·Aayam LamichhaneHiroshi Kiyonoa
Oct 1, 1990·Infection and Immunity·D R Hill, R Pohl

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