In vivo immunomodulatory effects of ixodid ticks on ovine circulating T- and B-lymphocytes

Parasite Immunology
Dharmendra K V BoppanaS Gomathinayagam

Abstract

Selected aspects of the ovine immune system were examined during the course of repeated infestations with the ixodid ticks, Haemaphysalis bispinosa and Hyalomma anatolicum anatolicum that naturally infest sheep, either individually or together. By the use of flow cytometry it was shown that total T-lymphocyte numbers were significantly reduced from the sixth through the ninth days of all infestations. Gamma/delta (gammadelta+) and CD8+ T-lymphocytes were significantly depleted during tick feeding in all infested groups. CD4+ T-lymphocyte levels were significantly increased during secondary H. bispinosa and mixed species infestations. Hyalomma anatolicum anatolicum caused a significant increase in circulating B-lymphocytes over several days in both initial and secondary infestations. All infested sheep had increased CD4/CD8 and decreased T/B lymphocyte ratios during exposure to both ticks. Bromodeoxyuridine (BrdU) ELISA was used to measure in vitro proliferation of peripheral blood mononuclear cells stimulated with the T-lymphocyte mitogen Concanavalin A (Con A) after their collection from infested sheep. Significant suppression of in vitro proliferation occurred during first and secondary infestations with H. bispinosa, H. a. a...Continue Reading

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Citations

Jul 21, 2015·Journal of Proteomics·Jan KotálJindřich Chmelař
Dec 19, 2006·Insect Biochemistry and Molecular Biology·Francisco J Alarcon-ChaidezStephen K Wikel
Mar 8, 2018·Artificial Organs·Ina Laura PieperCatherine A Thornton
Apr 16, 2005·Clinical Microbiology Reviews·Allen C Cheng, Bart J Currie
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Médiha Khamassi KhbouMohamed Gharbi
Jun 19, 2021·Nature Communications·Adela S Oliva ChávezJoao H F Pedra

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