In vivo-induced suppression of T cell proliferation: the relationship between the specificity of induction and control.

Cellular Immunology
C E MackewiczE Benjamini

Abstract

We have previously shown that sc immunization of C57BL/10 (H-2b) mice with the tobacco mosaic virus protein (TMVP) or with its tryptic peptide number 8, representing residues 93-112 of TMVP, induces T cells which proliferate in vitro in response to TMVP and to peptide 8. In contrast, immunization of B10.BR (H-2k) mice either with TMVP or with peptide 8 induces T cells which respond in vitro to the homologous but not the heterologous Ag. In the present article , we report that in the B10.BR (H-2k) strain, ip prepriming with (TMVP) 7 days prior to sc immunization with peptide 8 causes a drastic reduction in the in vitro proliferative response of peptide 8-specific T cells while no such effect is seen in the congenic C57BL/10 (H-2b) strain. This suppression of T cell responsiveness can be transferred with TMVP-primed spleen cells. Moreover, deleting T cells from the transferred spleen cells abrogates the suppressive effect. In both H-2 haplotypes, ip prepriming with peptide 8 causes suppression of the proliferative T cell response induced by subsequent immunization with peptide 8. This prepriming has no effect on the response to TMVP immunization of B10.BR mice but does effect the response of C57BL/10 mice. Using various synthetic...Continue Reading

References

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M SchwartzB Benacerraf
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Turkin, E E Sercarz
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Okamoto, M L Kripke
Aug 1, 1957·Virology·H FRAENKEL-CONRAT
Nov 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·A TsugitaW M Stanley

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