Mar 15, 2003

In vivo inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate

Indian Journal of Experimental Biology
H Ramachandra Prabhu


Intraperitoneal injection of rats with diethyldithiocarbamate (1.2 g/kg body wt) led to maximum diminution of superoxide dismutase activity at 1 hr by 86 and 84% in liver and red blood cell respectively with a gradual return to the normal level at 48 hr after administration of injection. Significant inhibition of selenium-dependent glutathione peroxidase was also observed, which returned to normal at 48 hr after administration of injection. However, maximum decline in its activity was at 12 hr by 52 and 73% in liver and red blood cells respectively. No significant difference in tissue level of selenium-independent glutathione peroxidase was observed during time course study after diethyldithiocarbamate administration. It is possible that inhibition of superoxide dismutase by diethyldithiocarbamate leads to accumulation of superoxide anion which in turn inactivates selenium-dependent glutathione peroxidase by its reaction with selenium at the active site of the enzyme.

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Mentioned in this Paper

Red blood cells, blood product
Selenoglutathione Peroxidase
Ditiocarb, Tin(4+) Salt
Glutathione Peroxidase
Metabolic Inhibition
Selenium Measurement
Red Blood Cell Count Measurement
Selenium-independent glutathione peroxidase
Ag-Zn Superoxide Dismutase

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