In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus

Neuroscience
T M Gao, Z C Xu

Abstract

Pyramidal neurons in the CA1 field of the hippocampus die a few days after transient cerebral ischemia. Excessive excitatory synaptic activation following reperfusion is thought to be responsible for such delayed cell death. However, it remains controversial whether excitatory synaptic transmission in the CA1 field is increased following reperfusion. Here we report a novel postsynaptic potential evoked from CA1 pyramidal neurons preceding cell death after transient forebrain ischemia with intracellular recording and staining techniques in vivo. This result indicates the dramatic alteration of synaptic transmission in CA1 neurons after transient ischemia. The ischemia-induced postsynaptic potential may be associated with the postischemic neuronal injury.

References

May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P AndinéH Hagberg
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroW A Pulsinelli
Mar 1, 1991·Neurochemical Research·K KrnjevićL Zhang
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·H S ChangN F Kassell
Jan 1, 1989·Experimental Brain Research·G BuzsàkiP Somogyi
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Apr 1, 1982·The Journal of Physiology·J J Hablitz, I A Langmoen
Jun 1, 1994·Current Opinion in Neurobiology·P Jonas, N Spruston
Jun 1, 1994·Current Opinion in Neurobiology·K W RocheR L Huganir

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Citations

Apr 29, 1998·Progress in Neurobiology·D Corbett, S Nurse
Nov 15, 1996·Neuroscience Letters·H Kawasaki, M Avoli
Sep 25, 2003·Lancet Neurology·Paolo CalabresiGiorgio Bernardi
Nov 1, 2006·Journal of Neuroscience Research·Yi-Wen RuanZao C Xu
Oct 6, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H MilaniL A Favero-Filho
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ren-Zhi ZhanRochelle D Schwartz-Bloom

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