In vivo linear microcracks of human femoral cortical bone remain parallel to osteons during aging

Bone
Nicholas WassermanOzan Akkus

Abstract

Previous studies have examined the density of microdamage within the cortex of long bones mostly from the viewpoint that is perpendicular to the long axis of the bone. The goal of the present work is to conduct a systematic characterization of the microcracks from a viewpoint that is parallel to the long axis of a load-bearing bone, the femur, so as to gain a better understanding of the size, shape and orientation of the microdamage. Longitudinal cross sections were taken at the mid-diaphysis of femurs from 13 male donors (23-85 years old) after being stained with basic fuchsin. The number of cracks, their lengths and orientation with respect to osteons were characterized using brightfield and UV-epifluorescent imaging. The mean crack density was 0.1118+/-0.0417 mm(-2) in the longitudinal plane and it significantly increased with age. The median crack length along the longitudinal plane did not change with age. The crack length in the posterior quadrant was significantly lower than anterior, medial and lateral quadrants. Less than 3% of the cracks were longer than 1 mm, indicating the presence of 'in vivo macroscopic' cracks in bone tissue. It was observed that the 99% of the cracks had angles that were less than 25 degrees wit...Continue Reading

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Citations

Jan 25, 2012·Calcified Tissue International·Monika RumplerKlaus Klaushofer
Jul 13, 2011·Journal of Bone and Mineral Metabolism·Brigitte Burt-PichatRoland Chapurlat
Jan 22, 2011·Biomechanics and Modeling in Mechanobiology·Vu-Hieu NguyenSalah Naili
Apr 14, 2012·Journal of Theoretical Biology·Gerardo PresbiteroDavid Taylor
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·K J KoesterR O Ritchie
Apr 14, 2015·Advanced Healthcare Materials·Elizabeth A Zimmermann, Robert O Ritchie
Oct 12, 2014·Bone·Tengteng TangRizhi Wang
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Jun 14, 2013·Journal of Biomechanical Engineering·Serife Agcaoglu, Ozan Akkus
Mar 30, 2019·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Yue ZhangJacky Chen

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