In vivo longitudinal MRI and behavioral studies in experimental spinal cord injury.

Journal of Neurotrauma
Laura M SundbergPonnada A Narayana

Abstract

Comprehensive in vivo longitudinal studies that include multi-modal magnetic resonance imaging (MRI) and a battery of behavioral assays to assess functional outcome were performed at multiple time points up to 56 days post-traumatic spinal cord injury (SCI) in rodents. The MRI studies included high-resolution structural imaging for lesion volumetry, and diffusion tensor imaging (DTI) for probing the white matter integrity. The behavioral assays included open-field locomotion, grid walking, inclined plane, computerized activity box performance, and von Frey filament tests. Additionally, end-point histology was assessed for correlation with both the MRI and behavioral data. The temporal patterns of the lesions were documented on structural MRI. DTI studies showed significant changes in white matter that is proximal to the injury epicenter and persisted to day 56. White matter in regions up to 1 cm away from the injury epicenter that appeared normal on conventional MRI also exhibited changes that were indicative of tissue damage, suggesting that DTI is a more sensitive measure of the evolving injury. Correlations between DTI and histology after SCI could not be firmly established, suggesting that injury causes complex pathological...Continue Reading

References

Aug 1, 1987·Neurochemical Pathology·P DemediukL A Horrocks
Apr 1, 1985·Experimental Neurology·L J Noble, J R Wrathall
Mar 15, 1969·British Medical Journal·R T Nolan
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Oct 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J C FalconerS J Liu
Feb 1, 1997·Investigative Radiology·V M RungeD A Blades
Feb 4, 1998·Journal of Computer Assisted Tomography·R P WoodsJ C Mazziotta
Dec 19, 1998·Magnetic Resonance Imaging·D A Fenyes, P A Narayana
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P NarayanaD Johnston
Nov 14, 2000·Brain Research·G A MetzK Fouad
Oct 5, 2001·Clinical Neuropharmacology·R J DumontA S Dumont
Apr 3, 2002·Journal of Clinical Epidemiology·Jos Twisk, Wieke de Vente
Oct 23, 2004·Journal of Neuroscience Research·Ponnada A NarayanaRussell Vang
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saaussan MadiPonnada A Narayana
Apr 28, 2005·Current Pharmaceutical Design·Hari Shanker Sharma
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Jul 29, 2005·Journal of Neurophysiology·V F LyalkaT G Deliagina
Jan 18, 2006·Computer Methods and Programs in Biomedicine·Hangyi JiangSusumu Mori
Jan 25, 2006·Journal of Neurotrauma·John C GenselJacqueline C Bresnahan
Feb 4, 2006·Journal of Neuroscience Research·Aparna A DeoPonnada A Narayana
May 9, 2006·Neurorehabilitation and Neural Repair·B Timothy HimesItzhak Fischer
May 23, 2006·Physiology·Tatiana G DeliaginaIrina N Beloozerova
Sep 9, 2006·Experimental Neurology·Lillian Cruz-OrengoJorge D Miranda
Mar 28, 2007·Journal of Neuroscience Research·Lisa D CainDavid J McAdoo
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew D BuddeSheng-Kwei Song
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Joong Hee KimSheng-Kwei Song
Aug 10, 2007·The Journal of Spinal Cord Medicine·Daniel LammertseUNKNOWN National Institute on Disability and Rehabilitation
Sep 18, 2007·Journal of Neuroscience Research·Juan J HerreraPonnada A Narayana
Nov 27, 2007·Neuroscience and Biobehavioral Reviews·Jirí SedýEva Syková
Jan 15, 2008·Journal of Neuroscience Research·K H BockhorstJ R Perez-Polo

❮ Previous
Next ❯

Citations

Jun 21, 2013·Journal of Neurotrauma·Michael B JirjisBrian D Schmit
Jul 18, 2014·Neurosurgery·Aditya VedantamShekar N Kurpad
Jun 9, 2015·NMR in Biomedicine·Wendy OakdenGreg J Stanisz
Apr 16, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nathan P SkinnerMatthew D Budde
Feb 14, 2012·Clinical Neurology and Neurosurgery·P W StromanM G Fehlings
Sep 7, 2016·NMR in Biomedicine·Yoram CohenDarya Morozov
Sep 26, 2013·Neurosurgery·Aditya VedantamShekar N Kurpad
Jan 10, 2018·Frontiers in Neuroscience·Matthew D BuddeShekar N Kurpad
Jul 1, 2020·Journal of Neuropathology and Experimental Neurology·Svenja RinkDoychin N Angelov
Nov 17, 2020·Frontiers in Veterinary Science·Ronaldo C da CostaUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)

❮ Previous
Next ❯

Software Mentioned

ParaVision
Pro Plus
ImagePro Plus
AIR
Photobeam Activity System ( PAS
Image
DTI Studio
Spot
STATA
DTI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.