PMID: 11934231Apr 6, 2002Paper

In vivo lung deposition of hollow porous particles from a pressurized metered dose inhaler

Pharmaceutical Research
Peter H HirstS P Newman

Abstract

PulmoSphere particles are specifically engineered for delivery by the pulmonary route with a hollow and porous morphology, physical diameters < 5 microm, and low tap densities (circa 0.1 g x cm(-3)). Deposition of PulmoSphere particles in the human respiratory tract delivered by pressurized metered dose inhaler (pMDI) was compared with deposition of a conventional micronized drug pMDI formulation. Nine healthy nonsmoking subjects (5 male, 4 female) completed a two-way crossover gamma scintigraphic study, assessing the lung and oropharyngeal depositions of albuterol sulfate, formulated as 99mTc-radiolabeled PulmoSphere particles or micronized particles (Ventolin Evohaler, GlaxoSmithKline, Ltd.) suspended in HFA-134a propellant. Mean (standard deviation) lung deposition, (% ex-valve dose) was doubled for the PulmoSphere formulation compared with Evohaler pMDI (28.5 (11.3) % vs. 14.5 (8.1) %, P < 0.01), whereas oropharyngeal deposition was reduced (42.6 (9.0) % vs. 72.0 (8.0) %, P < 0.01). Both PulmoSphere and Evohaler pMDIs gave uniform deposition patterns within the lungs. These data provided "proof of concept" in vivo for the PulmoSphere technology as a method of improving targeting of drugs to the lower respiratory tract from ...Continue Reading

Citations

Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Andrew R Clark
Dec 19, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Stephen NewmanKirby L Zeman
Feb 25, 2014·AAPS PharmSciTech·Yung Sung Cheng
Mar 7, 2014·Therapeutic Delivery·Jeffry Weers, Thomas Tarara
Aug 17, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Conor A RuzyckiWarren H Finlay
Jul 16, 2008·Soft Matter·Owen R DaviesSnow Stolnik
May 11, 2007·Expert Opinion on Drug Delivery·Jeffry G WeersAndrew R Clark
Jan 25, 2007·Pharmaceutical Research·Albert H L ChowBoris Y Shekunov
Jul 19, 2017·Pharmaceutical Research·James B FinkArmèle Dornelas de Andrade
Sep 29, 2011·Future Medicinal Chemistry·David Lechuga-BallesterosSarvajna K Dwivedi
Dec 12, 2012·Drug Development and Industrial Pharmacy·Kevin P O'Donnell, Robert O Williams
Nov 22, 2005·Expert Opinion on Drug Delivery·Philippe Rogueda
Dec 11, 2013·Pharmaceutical Development and Technology·Poom Bunchatheeravate, Jennifer S Curtis
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ting-Ting YangWei-Fen Zhang
Oct 7, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Sabine HäussermannGerhard Scheuch
Jan 28, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Omar S UsmaniWilfried De Backer
Sep 27, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lianjun ShiCory Berkland
Aug 31, 2021·Advanced Drug Delivery Reviews·Michael Yee Tak ChowPhilip Chi Lip Kwok

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