In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease

Neurobiology of Aging
Laura SerraMarco Bozzali

Abstract

We assessed here functional connectivity changes in the locus coeruleus (LC) and ventral tegmental area (VTA) of patients with Alzheimer's disease (AD). We recruited 169 patients with either AD or amnestic mild cognitive impairment due to AD and 37 elderly controls who underwent cognitive and neuropsychiatric assessments and resting-state functional magnetic resonance imaging at 3T. Connectivity was assessed between LC and VTA and the rest of the brain. In amnestic mild cognitive impairment patients, VTA disconnection was predominant with parietal regions, while in AD patients, it involved the posterior nodes of the default-mode network. We also looked at the association between neuropsychiatric symptoms (assessed by the neuropsychiatric inventory) and VTA connectivity. Symptoms such as agitation, irritability, and disinhibition were associated with VTA connectivity with the parahippocampal gyrus and cerebellar vermis, while sleep and eating disorders were associated with VTA connectivity to the striatum and the insular cortex. This suggests a contribution of VTA degeneration to AD pathophysiology and to the occurrence of neuropsychiatric symptoms. We did not find evidence of LC disconnection, but this could be explained by the...Continue Reading

Citations

Jan 30, 2020·Human Brain Mapping·Thomas LiebeMartin Walter
Jul 18, 2020·Reviews in the Neurosciences·Tommaso SchirinziLuca Marsili
Mar 11, 2019·Aging·Marco BozzaliLaura Serra
May 10, 2020·Alzheimer Disease and Associated Disorders·Juri KitamuraKazuomi Kario
Jun 4, 2019·Frontiers in Molecular Neuroscience·Paraskevi KrashiaMarcello D'Amelio
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Daniele CaligioreGianluca Baldassarre
Oct 1, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel R BatemanUNKNOWN International Society to Advance Alzheimer's Research and Treatment (ISTAART), Neuropsychiatric Syndromes Professional Inter
May 12, 2020·Journal of Alzheimer's Disease : JAD·Leonardo IaccarinoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 3, 2020·Progress in Neurobiology·Brianne A KentHaakon B Nygaard
Jan 27, 2021·Neuroscience and Biobehavioral Reviews·Francesco Fornai, Stefano Puglisi-Allegra
Feb 2, 2021·Neurobiology of Aging·Sara OberrauchLaura H Jacobson
Oct 31, 2020·Frontiers in Neuroscience·Michael KelbermanDavid Weinshenker
Mar 5, 2021·Brain, Behavior, and Immunity·Tiziana CarandiniMarco Bozzali
May 4, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laura SerraMarco Bozzali
May 1, 2021·Journal of Clinical Medicine·Ágoston PatthyAlán Alpár
Jun 29, 2021·Experimental Gerontology·Alessandra GalloRomain Verpillot
Aug 31, 2021·Multiple Sclerosis and Related Disorders·Tiziana CarandiniMara Cercignani
Nov 14, 2021·Alzheimer's Research & Therapy·Arianna SalaDaniela Perani

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