In Vivo Mapping of the Choriocapillaris in Healthy Eyes: A Widefield Swept-Source OCT Angiography Study

Ophthalmology Retina
Enrico BorrelliRodolfo Mastropasqua

Abstract

To report variation of choriocapillaris flow in peripapillary, macular, and near- and mid-periphery regions in healthy participants using widefield swept-source (SS) OCT angiography (OCTA). Prospective, cross-sectional study. Fifty healthy participants. Healthy young participants were imaged with the SS OCTA system (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA). OCT angiography scans were obtained in primary and extreme gazes and a montage was created automatically. The en face choriocapillaris images then were exported to ImageJ software version 1.50 (National Institutes of Health, Bethesda, MD), and a semiautomated algorithm was used for subsequent quantitative analysis. Quantitative analysis of the choriocapillaris performed in 3 different regions: (1) peripapillary, (2) macular, and (3) periphery. In addition, choriocapillaris variables were investigated further in distinct fields within these 3 different regions. Fifty eyes (50 participants) were included in the analysis. Mean age ± standard deviation was 25.2±5.1 years (median, 24.5 years; range, 20.0-40.0 years). The peripapillary region exhibited the greatest total signal void area (P < 0.0001 vs. the macular region; P < 0.0001 vs. the peripheral region). Within...Continue Reading

Citations

Aug 25, 2020·Translational Vision Science & Technology·Yong Sok JiSriniVas R Sadda
Oct 14, 2020·Eye·Federico CorviSrinivas R Sadda
May 8, 2021·Nature Reviews. Disease Primers·Monika FleckensteinEmily Y Chew
Dec 10, 2021·European Journal of Ophthalmology·Francisco de Asís Bartol-PuyalLuis Pablo

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