Abstract
In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured. For in vitro BPA exposure, primary hypothalamic NPCs from healthy newborns were utilized. In both cases, we studied the effects of BPA on NPC proliferation and differentiation, including putative signal and appetite factors. Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. With NPC differentiation, BPA exposure increased appetite peptide and reduced satiety peptide expression. In vitro BPA-treated control NPCs showed results that were consistent with in vivo data (increase appetite vs satiety peptide expression) and further showed a shift towards neuronal versus glia...Continue Reading
Citations
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Jessica M Rosin, Deborah M Kurrasch
Sep 29, 2018·Basic & Clinical Pharmacology & Toxicology·Jerrold J Heindel
Dec 1, 2018·Endocrinology·Neruja LoganathanDenise D Belsham
Mar 1, 2019·Scientific Reports·Surangrat ThongkornTewarit Sarachana
Jan 29, 2019·Frontiers in Endocrinology·Marilena MarraudinoStefano Gotti
May 23, 2020·Nutrients·Morgane FrapinValérie Amarger
Feb 27, 2020·Membranes·Roziana KamaludinJuhana Jaafar
Nov 27, 2019·Scientific Reports·Adebola A Adeyi, Babafemi A Babalola
Aug 1, 2019·Current Neuropharmacology·Antonietta SantoroRosaria Meccariello
Sep 23, 2020·Endocrinology·Neruja LoganathanDenise D Belsham
May 8, 2020·Brain Research Bulletin·Dan WuLihong Jia
Oct 15, 2019·Environmental Pollution·Ecem Fatma KaramanSibel Ozden
May 30, 2021·Science Advances·Dinushan NesanDeborah M Kurrasch
Jun 3, 2021·International Journal of Molecular Sciences·Jin-Xian LiaoChih-Yao Hou
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming-Kuei ShihChih-Yao Hou
Jul 18, 2021·Appetite·Paula NuñezCarmen Perillan