In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Govindasamy IlangovanP Kuppusamy

Abstract

Tumor tissue oxygenation is an important parameter that is positively correlated to the chemo- or radiation treatment outcome of certain tumors. Hence, methods to accurately and noninvasively determine the concentration of oxygen (pO2) in tumors will be valuable. In this study, electron paramagnetic resonance (EPR) spectroscopy, utilizing microcrystalline particulates of lithium phthalocyanine (LiPc), was used to perform repeated measurements of pO2 as a function of tumor growth. We permanently embedded the particulates in the tumor by coimplanting them with RIF-1 tumor cells during inoculation in mice. This procedure enabled repeated measurements of oxygen concentration in the tumor to be obtained for >2 weeks during its growth phase. The particulates were stable and nontoxic to the tumor cells. Both an in vitro clonogenic assay and an in vivo tumor growth rate examination in C3H mice showed no apparent effect on cell proliferation or tumor growth rate. The measurements indicated that the pO2 of the tumor decreased exponentially with tumor growth and reached hypoxic levels ( approximately 4 mmHg) within 4 days after inoculation of the tumor cells. Spatial EPR imaging revealed a nonuniform distribution of the embedded particula...Continue Reading

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Citations

Dec 17, 2008·Biomedical Microdevices·Edward EtesholaPeriannan Kuppusamy
Mar 26, 2009·Biomedical Microdevices·Guruguhan MeenakshisundaramPeriannan Kuppusamy
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Aug 1, 2007·Antioxidants & Redox Signaling·Deepti S VikramPeriannan Kuppusamy
Sep 23, 2010·Molecular Cancer Research : MCR·Ragu KanagasabaiGovindasamy Ilangovan
Dec 17, 2009·Journal of Magnetic Resonance·Guruguhan MeenakshisundaramPeriannan Kuppusamy
Oct 16, 2015·Free Radical Biology & Medicine·Juliane FrankKarsten Mäder
Jun 10, 2008·Journal of Magnetic Resonance·Subhojit SomPeriannan Kuppusamy
Sep 11, 2007·The Medical Clinics of North America·Amy Pope-HarmanMauro Ferrari
May 16, 2008·Journal of Magnetic Resonance·Deepti S VikramPeriannan Kuppusamy
Jan 30, 2007·Biophysical Journal·Anna BrataszPeriannan Kuppusamy
Apr 1, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ayano EnomotoMurali C Krishna
Oct 3, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maciej M KmiecPeriannan Kuppusamy
Jun 24, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ken-ichiro MatsumotoMartin J Lizak
Apr 26, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anna BrataszPeriannan Kuppusamy
Aug 24, 2019·Cell Biochemistry and Biophysics·Michal GonetMartyna Elas
May 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexandre SamouilovJay L Zweier

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