In vivo measurement of the longitudinal relaxation time of arterial blood (T1a) in the mouse using a pulsed arterial spin labeling approach

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
David L ThomasRoger J Ordidge

Abstract

A novel method for measuring the longitudinal relaxation time of arterial blood (T1a) is presented. Knowledge of T1a is essential for accurately quantifying cerebral perfusion using arterial spin labeling (ASL) techniques. The method is based on the flow-sensitive alternating inversion recovery (FAIR) pulsed ASL (PASL) approach. We modified the standard FAIR acquisition scheme by incorporating a global saturation pulse at the beginning of the recovery period. With this approach the FAIR tissue signal difference has a simple monoexponential dependence on the recovery time, with T1a as the time constant. Therefore, FAIR measurements performed over a range of recovery times can be fitted to a monoexponential recovery curve and T1a can be calculated directly. This eliminates many of the difficulties associated with the measurement of T1a. Experiments performed in vivo in the mouse at 2.35T produced a mean value of 1.51 s for T1a, consistent with previously published values.

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Citations

Dec 29, 2011·Magma·Enrico De VitaDavid L Thomas
Apr 6, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fotios VlachosElisa Konofagou
Aug 24, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lingzhi HuSamuel A Wickline
Jun 22, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wen-Chau WuDanny J J Wang
Dec 28, 2012·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuki ShimadaHajime Tamura
May 3, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Clément S DebackerEmmanuel L Barbier
Jul 3, 2013·PloS One·Zhentao ZuoDanny J J Wang
Dec 3, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David T PilkintonRavinder Reddy
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jack A WellsDavid L Thomas
Jun 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jack A WellsFernando Calamante
Dec 17, 2009·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Luisa De RisioGloria Diane Shelton
Jul 13, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W Wouter OosterlinckU Himmelreich
Dec 13, 2019·NMR in Biomedicine·Michael Gottschalk
Oct 28, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patricia M WashingtonBarclay Morrison

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