In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis.

Journal of Biomedical Optics
Andrew J GomesVadim Backman

Abstract

Polarization-gated spectroscopy is an established method to depth-selectively interrogate the structural properties of biological tissue. We employ this method in vivo in the azoxymethane (AOM)-treated rat model to monitor the morphological changes that occur in the field of a tumor during early carcinogenesis. The results demonstrate a statistically significant change in the shape of the refractive-index correlation function for AOM-treated rats versus saline-treated controls. Since refractive index is linearly proportional to mass density, these refractive-index changes can be directly linked to alterations in the spatial distribution patterns of macromolecular density. Furthermore, we found that alterations in the shape of the refractive-index correlation function shape were an indicator of both present and future risk of tumor development. These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development.

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Citations

Feb 28, 2017·Journal of Biomedical Optics·Sónia CarvalhoValery V Tuchin
Nov 2, 2014·Biomedical Optics Express·Stephen Chad KanickBrian W Pogue
Apr 20, 2019·Optica·Zachary A SteelmanAdam Wax

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