In vivo measurements of blood flow in a rat using X-ray imaging technique.

The International Journal of Cardiovascular Imaging
Sung Yong JungSang Joon Lee

Abstract

To measure instantaneous velocity fields of venous blood flow in a rat using X-ray particle tracking method. Gold nanoparticles (AuNPs) incorporated chitosan microparticles were applied as biocompatible flow tracers. After intravenous injection of the AuNP-chitosan particles into 7- to 9-week-old male rat vein, X-ray images of particle movement inside the cranial vena cava were consecutively captured. Individual AuNP-chitosan particles in the venous blood flow were clearly observed, and the corresponding velocity vectors were successfully extracted. The measured velocity vectors are in good agreement with the theoretical velocity profile suggested by Casson. This is the first trial to measure blood flow in animals under in vivo conditions with X-ray imaging technique. The results show that X-ray particle tracking technique has a great potential for in vivo measurements of blood flow, which can extend to various biomedical applications related with the diagnosis of circulatory vascular diseases.

References

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Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C CansteinM Markl
Apr 2, 2009·The Review of Scientific Instruments·Sang Joon LeeSung Yong Jung
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Dec 22, 2009·Biosensors & Bioelectronics·Sang Joon LeeSungsook Ahn

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Citations

Apr 17, 2013·The International Journal of Cardiovascular Imaging·Hiram G BezerraErnst E van der Wall
May 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sungsook AhnSang Joon Lee
Apr 11, 2015·Advanced Drug Delivery Reviews·Benjamin S SchusterJustin Hanes
Sep 2, 2014·Journal of Synchrotron Radiation·Sang Joon LeeSung Yong Jung
Apr 18, 2013·Journal of Synchrotron Radiation·Sung Yong JungSang Joon Lee
Feb 16, 2013·Journal of Synchrotron Radiation·Sung Yong JungSang Joon Lee

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