PMID: 2097672Jan 1, 1990Paper

In vivo measures of monoamines during amphetamine-induced behaviors in rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
R Kuczenski, D S Segal

Abstract

1. Using a removable in vivo microdialysis probe, and remote sample collection, the temporal and dose-related behavioral and monoamine response to amphetamine (AMPH) were examined in freely-moving rats. Extracellular dopamine, serotonin and their metabolites were monitored concomitant with detailed characterization of the locomotor and stereotypy profiles. Consistent with previous results, AMPH (0.5-5.0 mg/kg) induced a rapid dose-dependent increase in dopamine concentration and decrease in the concentrations of the dopamine metabolites. Dopamine and metabolites exhibited contrasting temporal and dose-related patterns, suggesting that the decline in dopamine metabolites is functionally dissociated from the AMPH-enhanced dopamine release, and that metabolite levels do not provide an accurate index of functional dopaminergic activity. 2. Dose response comparisons revealed a significant relationship between AMPH-induced increases in behavioral perseveration and the magnitude and duration of the dopamine release. However, the temporal patterns of the neurotransmitter response and individual components of stereotypy were not parallel, suggesting that the presence of stereotypies is not associated simply with quantitative differences...Continue Reading

References

Jan 1, 1985·Neurochemistry International·B H Westerink

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Citations

Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·C OkudaR Kuczenski
Sep 1, 1993·Psychiatry Research·R J Kavoussi, E F Coccaro
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Jan 24, 2004·Behavioural Brain Research·Vanessa Erin Woods, Aaron Ettenberg
May 1, 2001·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Jun 28, 1992·Annals of the New York Academy of Sciences·P W KalivasP Duffy
Mar 15, 2005·Journal of Neuroscience Methods·Servet M YatinBertha K Madras
Jul 12, 2002·Synapse·Servet M YatinBertha K Madras
Jan 21, 2006·Stress : the International Journal on the Biology of Stress·Bart A EllenbroekHi-Joon Park

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