In Vivo Mercury Demethylation in a Marine Fish (Acanthopagrus schlegeli)

Environmental Science & Technology
Xun WangWen-Xiong Wang

Abstract

Mercury (Hg) in fish has attracted public attention for decades, and methylmercury (MeHg) is the predominant form in fish. However, the in vivo MeHg demethylation and its influence on Hg level in fish have not been well-addressed. The present study investigated the in vivo demethylation process in a marine fish (black seabream, Acanthopagrus schlegeli) under dietary MeHg exposure and depuration and quantified the biotransformation and interorgan transportation of MeHg by developing a physiologically based pharmacokinetic (PBPK) model. After exposure, we observed a 2-fold increase of the whole-body inorganic Hg (IHg), indicating the existence of an in vivo demethylation process. The results strongly suggested that the intestine played a predominant role in MeHg demethylation with a significant rate (6.6 ± 1.7 day-1) during exposure, whereas the hepatic demethylation appeared to be an extremely slow (0.011 ± 0.001 day-1) process and could hardly affect the whole-fish Hg level. Moreover, demethylation in the intestine served as an important pathway for MeHg detoxification. Our study also pointed out that in vivo MeHg demethylation could influence Hg level and speciation in fish although food is the major pathway for Hg accumulatio...Continue Reading

References

Jan 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I R RowlandP Grasso
Nov 1, 1984·Archives of Environmental Health·I R RowlandR A Doherty
Jan 7, 1998·Science·G M Egeland, J P Middaugh
Nov 6, 2001·Marine Pollution Bulletin·C R JoirisA Birkun
Jun 28, 2003·FEMS Microbiology Reviews·Tamar BarkayAnne O Summers
Feb 12, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Paul E DrevnickJames T Oris
Aug 21, 2008·Environmental Toxicology and Chemistry·Karen Van CampenhoutRonny Blust
Oct 22, 2008·Environmental Toxicology and Chemistry·Collin A Eagles-SmithTerrence L Adelsbach
Dec 17, 2008·Environmental Health Perspectives·Celia Y ChenMichael S Bank
May 25, 2010·Environmental Pollution·Rui WangWen-Xiong Wang
May 27, 2010·Chemical Research in Toxicology·Mohammad A K Khan, Feiyue Wang
Jul 17, 2010·Nature Geoscience·Tong Zhang, Heileen Hsu-Kim
Sep 8, 2011·Environmental Science & Technology·Benjamin D BarstAaron P Roberts
Jan 18, 2012·Environmental Pollution·Fei Dang, Wen-Xiong Wang
Apr 27, 2012·Environmental Health Perspectives·Emily OkenSusan Korrick
Jun 12, 2013·Environmental Science & Technology·Rui WangWen-Xiong Wang
Sep 28, 2013·Science·Marcia McNutt
Jul 28, 2015·Environmental Science & Technology·Xun Wang, Wen-Xiong Wang
Sep 16, 2015·Environmental Science & Technology·Merja LyytikäinenMervi Kunnasranta
Oct 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M VázquezV Devesa
Mar 29, 2016·Environmental Science & Technology·Xia LuBaohua Gu

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Citations

Dec 7, 2018·The Journal of Toxicological Sciences·Galen GuoHing Man Chan
Feb 2, 2018·Ambio·Collin A Eagles-SmithJennifer F Nyland
Jul 31, 2019·Environmental Toxicology and Chemistry·Anne FairbrotherBryan W Brooks
Sep 8, 2019·Bulletin of Environmental Contamination and Toxicology·Shifeng Yao, Ken G Drouillard
Sep 7, 2018·Ecotoxicology·Cyntia Ayumi Yokota HarayashikiKirsten Benkendorff
May 27, 2020·Rapid Communications in Mass Spectrometry : RCM·Zi-Yuan WangZhao-Ying Liu
Jun 29, 2021·Frontiers in Microbiology·Sarah E RothenbergBrianna R Beechler
Apr 19, 2018·Inorganic Chemistry·Sayani DasAnkona Datta
Jun 27, 2020·Environmental Pollution·Gaël Le CroizierDavid Point
Jan 7, 2022·Chemical Research in Toxicology·Jingjing PanWei Liu

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