PMID: 6405393Feb 1, 1983Paper

In vivo metabolism of dihomo-gamma-linolenic acid to bronchoactive products in the canine lung

Prostaglandins, Leukotrienes, and Medicine
E W SpannhakeP J Kadowitz

Abstract

We investigated the effects of dihomo-gamma-linolenic acid (DGLA), the fatty acid precursor to the monoenoic prostaglandins, on pulmonary mechanics in the intact chest, artificially ventilated dog. Under conditions of normal airway tone, intravenously administered DGLA produced a modest, dose-related increase in lung resistance and decrease in dynamic lung compliance. These responses were approximately 30-100 times less than those produced by arachidonic acid. The bronchoconstrictive responses to DGLA were abolished by prior inhibition of the cyclooxygenase with indomethacin. PGD1 was equal in activity to PGF1 alpha in causing constriction of central and peripheral airways of the dog. PGE1 was without significant airway effects in these animals under conditions of resting airway tone. We conclude that DGLA is a moderately good substrate for the cyclooxygenase pathway enzymes of the canine lung, producing products having a predominantly bronchoconstrictive effect. This bronchoconstriction is most likely due to the synthesis of PGD1 and PGF1 alpha and is not due to the synthesis of lipoxygenase pathway products.

References

Mar 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E W SpannhakeP J Kadowitz
Mar 1, 1976·Circulation Research·T C WicksP A Kot
Aug 11, 1972·Biochimica Et Biophysica Acta·E J Christ, D A van Dorp
Jul 4, 1981·Lancet·M C HolroydeE V Elliott
Nov 1, 1980·Acta Physiologica Scandinavica·P HedqvistB Samuelsson
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M DrazenE J Corey
Jun 1, 1964·British Journal of Pharmacology and Chemotherapy·I H MAIN

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Citations

Mar 30, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Antonia Dimitrakopoulou-StraussLudwig G Strauss
Feb 25, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Jan 13, 2016·European Journal of Nuclear Medicine and Molecular Imaging·C SachpekidisA Dimitrakopoulou-Strauss
Mar 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Antonia Dimitrakopoulou-StraussBernd Kasper
Mar 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ludwig G StraussAntonia Dimitrakopoulou-Strauss
Jun 7, 2018·Cancer Immunology, Immunotherapy : CII·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Nov 28, 2018·Cancer Immunology, Immunotherapy : CII·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Aug 31, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Christos SachpekidisA Dimitrakopoulou-Strauss

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