In vivo metabolite identification of bakuchiol in rats by UPLC/ESI-PDA-QTOF-MS

Fitoterapia
Chao HuXianju Huang

Abstract

Psoralea corylifolia L. is a traditional Chinese medicine for the treatment of various skin diseases such as psoriasis, vitiligo and chronic graft-versus-host. Bakuchiol, isolated from the seeds of P. corylifolia L., is one of the most important active compounds. To study the metabolic fate of bakuchiol in rats, an ultra performance liquid chromatography/electrospray ionization-photo diode array-quadrupole time of flight-mass spectrometry (UPLC/ESI-PDA-QTOF-MS) combined with MetaboLynx XS software was used, peak area-time curves of major metabolites in plasma from bakuchiol were determined. A total of 11 metabolites were identified after a single oral administration of bakuchiol, including 6 in plasma, 10 in bile, 8 in urine and 2 in feces, the metabolic transformation pathways of bakuchiol in rats included oxidation, hydroxylation, methylation, O-glucuronide conjugation and O-sulfate conjugation. In conclusion, this study expands our knowledge about the metabolism of bakuchiol which will be conducive to reveal its in vivo pharmacological and toxicological material basis, in addition, UPLC/ESI-PDA-QTOF-MS coupled with MetaboLynx XS software can be adopted as a useful tool for quick detection and identification of metabolites fr...Continue Reading

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Jan 15, 2013·Journal of Pharmaceutical and Biomedical Analysis·Xiaomei ZhuangHua Li
Jul 9, 2013·Fitoterapia·Bhawna ChopraKanaya Lal Dhar
Oct 12, 2013·Biomedical Chromatography : BMC·Shuang-Qing Zhang, Yu-Ming Fan

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Citations

Dec 30, 2015·Chemico-biological Interactions·Meina ChiJiang Zheng
Oct 8, 2017·Drug Testing and Analysis·Carina de Souza AnselmoFrancisco Radler de Aquino Neto
Aug 27, 2019·Drug Metabolism Reviews·Bo Wen, Peter Gorycki
Dec 14, 2019·Chinese Journal of Natural Medicines·Qi-Hang ZhouGuang-Bo Ge

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