In Vivo Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application

Biological & Pharmaceutical Bulletin
Hongyu ZhangNianping Feng

Abstract

In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solution. Based on in vivo microdialysis experiments, the drug concentration in local deep skin of rat increased rapidly and reached a peak concentration (Cmax) of 319.35±23.72 µg/mL at 180 min, and decreased slowly thereafter. The local area under the concentration-time curve (AUC)0-t was 3.81-fold higher than the compared aqueous suspension. The in vivo systemic pharmacokinetics were in agreement with the microdialysis results, in view of the Cmax and AUC0-t from liposomal group were both significantly higher (p<0.05) than the compared group. Liposome-associated transdermal psoralen delivery was significantly more effective than delivery via an aqueous suspension. The enhanced skin permeability may be associated with improved skin hydration, lipid exchange and fusion with the stratum corneum (SC), and changes in SC structure, promoting drug permeation into deep skin. After 10 h of treatment with the perfusate, the mi...Continue Reading

Citations

Mar 14, 2020·Medicinal Research Reviews·Daniel Sepúlveda-CrespoMaría Martínez-Valladares
Nov 25, 2020·Expert Opinion on Drug Delivery·Vamshi Krishna Rapalli, Gautam Singhvi
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sevgi Güngör, Emine Kahraman

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