PMID: 9423928Jan 10, 1998Paper

In vivo microdialysis study of GABA(A) and GABA(B) receptors modulating the glutamate receptor/NO/cyclic GMP pathway in the rat hippocampus

Neuropharmacology
E FedeleM Raiteri

Abstract

Intrahippocampal perfusion of bicuculline (50 microM) in Mg2+-free medium caused elevation of extracellular cGMP and epileptic-like behaviour. Both effects were partially prevented by blocking NMDA receptors with MK-801 or Mg2+ ions. Similarly, the GABA(B) receptor antagonists CGP52432 (0.1-30 microM) and CGP35348 (0.3-1 mM) evoked increases of extracellular cGMP. CGP52432 also elicited behavioural responses ranging from wet dog shakes to convulsions. MK-801 or Mg2+ ions reduced the effects of CGP52432. Local application of muscimol (100-300 microM) or (-)baclofen (300 microM) caused inhibition of extracellular cGMP. Administration of the AMPA/kainate receptor antagonist NBQX (100 microM) caused cGMP elevation which was almost abolished by co-perfusion of muscimol and (-)baclofen. In the presence of physiological Mg2+, perfusion of AMPA (30 microM) failed to affect cGMP levels, although rats displayed wet dog shakes episodes. When AMPA was co-perfused with low concentrations of bicuculline or CGP52432, cGMP elevations were observed in 60% of the rats. Addition of both antagonists to AMPA resulted in 85% of rats displaying a cGMP response. To conclude: (a) extracellular hippocampal cGMP is controlled by inhibitory GABA(A) and GA...Continue Reading

References

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Citations

May 13, 1999·Progress in Neurobiology·E Fedele, M Raiteri
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kim FejginDaniel Klamer
Dec 18, 2003·The Journal of Physiology·Samuel G A Frère, Anita Lüthi
Jun 9, 2011·British Journal of Pharmacology·O BrunoR Ricciarelli
Jul 13, 2006·European Journal of Pharmacology·Isabel R FragataAna M Sebastião
Sep 3, 2005·Life Sciences·Scott M RawlsRonald J Tallarida
Aug 18, 2004·Neurochemistry International·Olimpia PepicelliErnesto Fedele

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