Abstract
A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology. To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers. Forty-seven patients with a total of 54 lesions (18 AK, 12 BD and 24 SCC) were included in the study. D-OCT still images of AK, BD and SCC at three predefined skin depths were prepared and randomized, creating a study set of 162 D-OCT images. Three observers performed blinded evaluations of the randomized study set assessing multiple parameters including the different types of vascular morphology. Non-blinded quantitative measurements of vascular diameter were also performed. The blinded observer analysis suggests that D-OCT evaluation of the vascular morphology may aid in distinguishing AK, BD and SCC lesions. We identified two vascular shapes that presented significantly differently ...Continue Reading
References
May 4, 1989·Nature·J FolkmanD Hanahan
Jan 14, 1999·Carcinogenesis·M F BolontradeC J Conti
Feb 22, 2000·British Journal of Cancer·S StriethN E Fusenig
Jul 8, 2003·The Journal of Pathology·Cheryl W S ChinJames Lowe
Jun 25, 2004·The British Journal of Dermatology·I ZalaudekH Kerl
Dec 22, 2004·Archives of Dermatology·Giuseppe ArgenzianoH Peter Soyer
Mar 1, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·I ZalaudekG Argenziano
Oct 3, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ketty PerisMaria Concetta Fargnoli
Aug 16, 2011·Journal of the American Academy of Dermatology·Iris ZalaudekGiuseppe Argenziano
Apr 3, 2012·Actas dermo-sifiliográficas·J M MartínE Jordá
Jul 27, 2012·Tutorials in Quantitative Methods for Psychology·Kevin A Hallgren
Sep 19, 2012·Archives of Dermatology·Cliff RosendahlHarald Kittler
Nov 6, 2012·Journal of Skin Cancer·Kelly E Johnson, Traci A Wilgus
Feb 1, 2013·Annals of Plastic Surgery·Hamid TehraniMilind Dalal
Oct 19, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·L SchmitzT Dirschka
Jan 7, 2015·Current Problems in Dermatology·Iris Zalaudek, Giuseppe Argenziano
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·N De CarvalhoG Pellacani
Feb 27, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·L ThemstrupG B E Jemec
Apr 23, 2016·Dermatology : International Journal for Clinical and Investigative Dermatology·Martina UlrichJulia Welzel
May 29, 2016·Microvascular Research·L ThemstrupG B E Jemec
Citations
May 3, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·J OlsenG B E Jemec
May 19, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J Welzel, S Schuh
May 8, 2018·Experimental Dermatology·Pernille Lindsø AndersenGregor Borut Ernst Jemec
Jun 13, 2018·Skin Pharmacology and Physiology·Sebastian BatzJürgen Lademann
Sep 16, 2018·Experimental Dermatology·Nathalie De CarvalhoGiovanni Pellacani
Feb 9, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mengyang Liu, Wolfgang Drexler
Jan 18, 2019·Journal of Biophotonics·Cristel RuiniTanja von Braunmühl
Feb 2, 2019·Physics in Medicine and Biology·Anthony J Deegan, Ruikang K Wang
Nov 14, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B HindelangU Darsow
Dec 8, 2017·Experimental Dermatology·Lotte ThemstrupGregor B E Jemec
Sep 26, 2020·The British Journal of Dermatology·B WanM D Lynch
Dec 11, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·J WelzelG Pellacani
Feb 10, 2021·Journal of Biophotonics·Chu ZhouXiuli Wang
Mar 23, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·An-Qi ZhuHui-Xiong Xu
Jun 11, 2021·Archives of Dermatological Research·Jonas OlsenGregor Borut Ernst Jemec
Jul 15, 2021·Journal of Biophotonics·Yubo JiZhihong Huang
Aug 21, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C RuiniE C Sattler
Oct 27, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Cristel RuiniElke C Sattler
Nov 24, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jessica G LabadieJeffrey S Dover