In vivo microvascular structural and functional consequences of muscle length changes

The American Journal of Physiology
David C PooleCasey A Kindig

Abstract

As muscles are stretched, blood flow and oxygen delivery are compromised, and consequently muscle function is impaired. We tested the hypothesis that the structural microvascular sequellae associated with muscle extension in vivo would impair capillary red blood cell hemodynamics. We developed an intravital spinotrapezius preparation that facilitated direct on-line measurement and alteration of sarcomere length simultaneously with determination of capillary geometry and red blood cell flow dynamics. The range of spinotrapezius sarcomere lengths achievable in vivo was 2.17 +/- 0.05 to 3.13 +/- 0.11 microns. Capillary tortuosity decreased systematically with increases of sarcomere length up to 2.6 microns, at which point most capillaries appeared to be highly oriented along the fiber longitudinal axis. Further increases in sarcomere length above this value reduced mean capillary diameter from 5.61 +/- 0.03 microns at 2.4-2.6 microns sarcomere length to 4.12 +/- 0.05 microns at 3.2-3.4 microns sarcomere length. Over the range of physiological sarcomere lengths, bulk blood flow (radioactive microspheres) decreased approximately 40% from 24.3 +/- 7.5 to 14.5 +/- 4.6 ml.100 g-1.min-1. The proportion of continuously perfused capillari...Continue Reading

Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J K BaileyD C Poole
Jan 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takashi SonobeYutaka Kano
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May 11, 2004·Journal of Applied Physiology·Yutaka KanoTimothy I Musch
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