In Vivo Models for Cholangiocarcinoma-What Can We Learn for Human Disease?

International Journal of Molecular Sciences
Raphael MohrChristoph Roderburg

Abstract

Cholangiocarcinoma (CCA) comprises a heterogeneous group of primary liver tumors. They emerge from different hepatic (progenitor) cell populations, typically via sporadic mutations. Chronic biliary inflammation, as seen in primary sclerosing cholangitis (PSC), may trigger CCA development. Although several efforts were made in the last decade to better understand the complex processes of biliary carcinogenesis, it was only recently that new therapeutic advances have been achieved. Animal models are a crucial bridge between in vitro findings on molecular or genetic alterations, pathophysiological understanding, and new therapeutic strategies for the clinic. Nevertheless, it is inherently difficult to recapitulate simultaneously the stromal microenvironment (e.g., immune-competent cells, cholestasis, inflammation, PSC-like changes, fibrosis) and the tumor biology (e.g., mutational burden, local growth, and metastatic spread) in an animal model, so that it would reflect the full clinical reality of CCA. In this review, we highlight available data on animal models for CCA. We discuss if and how these models reflect human disease and whether they can serve as a tool for understanding the pathogenesis, or for predicting a treatment re...Continue Reading

References

Jan 1, 1991·Toxicologic Pathology·R R MaronpotR D Irwin
Nov 22, 1991·Science·J M Adams, S Cory
Jan 1, 1989·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H DashtiS Bengmark
Jan 1, 1984·Experimental Pathology·M M Praet, H J Roels
Mar 21, 2000·Genesis : the Journal of Genetics and Development·C Postic, M A Magnuson
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle Sansal, William R Sellers
Oct 11, 2005·Lancet·Shahid A KhanSimon D Taylor-Robinson
Mar 22, 2006·Molecular Carcinogenesis·Watcharin LoilomeMasanao Miwa
Apr 26, 2007·Annals of Surgery·Michelle L DeOliveiraRichard D Schulick
Aug 10, 2007·Nature Reviews. Cancer·Kristopher K Frese, David A Tuveson
Dec 18, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alphonse E SiricaJennifer L Dewitt
May 19, 2009·Experimental Animals·Kazuyuki MekadaAtsushi Yoshiki
Aug 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Banchob SripaJeffrey M Bethony
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian D FingasGregory J Gores
Jun 8, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yu-Jie HouHong-Yang Wang
Jun 23, 2011·Scandinavian Journal of Gastroenterology·Thomas von HahnNisar P Malek
Jul 26, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco MarzioniStefan Nilsson
Aug 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandru V OlaruFlorin M Selaru
Jan 24, 2012·Cancer Research·Michael R O'DellAram F Hezel
Apr 10, 2012·Gastroenterology·Jinqiang ZhangTong Wu
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne M HorganJennifer J Knox
Jul 17, 2012·The Journal of Clinical Investigation·Biao FanHolger Willenbring
Aug 8, 2012·Chemical Research in Toxicology·Heather HajovskyRobert P Hanzlik
Nov 28, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Samuele De MinicisMarco Marzioni
Jan 29, 2013·Journal of Gastroenterology·Hong-Jae JoSae-Ock Oh
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Engin GürlevikFlorian Kühnel

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Citations

Nov 24, 2020·Expert Opinion on Investigational Drugs·Leonardo BaiocchiGianfranco Alpini
Jan 30, 2021·Expert Opinion on Investigational Drugs·Scott H Waddell, Luke Boulter

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