In vivo models of haemophilia - status on current knowledge of clinical phenotypes and therapeutic interventions

Haemophilia : the Official Journal of the World Federation of Hemophilia
K ØvlisenM Tranholm

Abstract

Animal models have contributed immensely to the understanding of and the improvement in treatment of haemophilia A and B. First, establishment of haemophilic dog colonies provided an invaluable opportunity to investigate the diseases and later, the advances in gene technologies resulting in small haemophilic animal models were a milestone in the preclinical research making it possible to address some of the many unanswered questions. This review provides an overview of animal models used in the study of haemophilia as well as a short overview of the contributions resulting from studies in these models.

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Citations

Nov 30, 2013·Arthritis Research & Therapy·Michael Karl BoettgerThomas Hilberg
Jul 27, 2010·Thrombosis Research·Gonzalo Hortelano
Jul 16, 2010·Journal of Thrombosis and Haemostasis : JTH·C J BoothP W Marks
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Jul 21, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·T ElmM Tranholm
Jul 13, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·Henrik Agersø, Mikael Tranholm
Jul 1, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·E S MolinaM A Demasi
Dec 1, 2009·Journal of Thrombosis and Haemostasis : JTH·C D PoradaG Almeida-Porada
Jan 20, 2016·Journal of Thrombosis and Haemostasis : JTH·K M LövgrenB Wiinberg
Jan 17, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Kåre Kryger VølsMaj Petersen
Oct 1, 2013·Cartilage·Monique E R van MeegerenSimon C Mastbergen
May 2, 2017·Journal of Toxicology·Caroline E RasmussenHanne Offenberg

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