In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies

The Journal of Infectious Diseases
Christopher C NixonJ Victor Garcia

Abstract

Current HIV therapy is not curative regardless of how soon after infection it is initiated or how long it is administered, and therapy interruption almost invariably results in robust viral rebound. Human immunodeficiency virus persistence is therefore the major obstacle to a cure for AIDS. The testing and implementation of novel yet unproven approaches to HIV eradication that could compromise the health status of HIV-infected individuals might not be ethically warranted. Therefore, adequate in vitro and in vivo evidence of efficacy is needed to facilitate the clinical implementation of promising strategies for an HIV cure. Animal models of HIV infection have a strong and well-documented history of bridging the gap between laboratory discoveries and eventual clinical implementation. More recently, animal models have been developed and implemented for the in vivo evaluation of novel HIV cure strategies. In this article, we review the recent progress in this rapidly moving area of research, focusing on the two most promising model systems: humanized mice and nonhuman primates.

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Citations

Dec 22, 2019·Virologica Sinica·Tian-Jiao FanJian-Hua Wang
Jan 24, 2020·Nature·Christopher C NixonJ Victor Garcia
Nov 23, 2017·Frontiers in Immunology·Jiae KimMangala Rao
Sep 10, 2019·Frontiers in Microbiology·Paul W DentonMartin Tolstrup
May 11, 2020·Current HIV/AIDS Reports·Veronica Obregon-PerkoAnn Chahroudi
Oct 17, 2019·Frontiers in Immunology·Gilles DarcisAlexander O Pasternak
Jan 24, 2020·Nature·Julia Bergild McBrienGuido Silvestri
Sep 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah S SperberSatish K Pillai
Oct 22, 2019·Biochemical Pharmacology·Arlisa AlisjahbanaTim Willinger
May 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dhanashree H Surve, Anil B Jindal
Mar 26, 2021·Clinical Pharmacology and Therapeutics·Courtney V FletcherSiddappa N Byrareddy
Jul 3, 2021·Frontiers in Microbiology·Cynthia LunguFrancesco A Procopio
Apr 8, 2020·Molecular Therapy. Methods & Clinical Development·Songlin YuXiaoping Chen

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