In vivo modulation of angiogenesis by beta 2 glycoprotein I

Journal of Autoimmunity
Freda H PassamSteven A Krilis

Abstract

Beta 2 glycoprotein I (β2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins. The aim of this study was to examine the angiogenic potential of β2GPI in vivo in β2GPI deficient mice utilizing angiogenic assays. β2GPI deficient mice show increased microvessel formation in comparison to β2GPI replete controls when injected with growth factor free-matrigel implants. However, microvessel formation in matrigel plugs of β2GPI deficient mice was less than in β2GPI replete mice when basic fibroblast growth factor (bFGF) was included in the matrigel. Hemoglobin content was higher in vascular endothelial growth factor (VEGF) containing-matrigel plugs in the β2GPI deficient mouse demonstrating that the lack of β2GPI led to increased extravasation by VEGF. Melanoma B16F10 tumour growth was enhanced in β2GPI deficient mice. Melanoma microvessel density was increased in β2GPI deficient mice but the proliferation rate of tumour cells (determined by Ki67 immunohistochemistry) was unaffected by the presence or absence of β2GPI. Subcutaneous delivery of native human β2GPI by the ALZET osmotic pump did not affect melanoma tumour growth in β2GPI deficient mice. We conclude tha...Continue Reading

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Citations

May 14, 2014·Autoimmunity Reviews·Silvia D'IppolitoNicoletta Di Simone
Mar 1, 2012·Journal of Autoimmunity·A G Tzioufas, P G Vlachoyiannopoulos
Jul 19, 2011·Autoimmunity Reviews·Carlo Selmi
May 4, 2011·Journal of Thrombosis and Haemostasis : JTH·P G de Groot, J C M Meijers
Oct 22, 2016·Thrombosis Journal·Fatima El-AssaadBill Giannakopoulos
Dec 23, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Giorgia MandiliPaolo Destefanis
Oct 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R PopeSherry D Fleming
Mar 9, 2020·Clinical Rheumatology·Gabriela MedinaLuis J Jara
May 28, 2021·Frontiers in Immunology·Yuan TanXiaoping Wan

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