In vivo modulation of CD1 and MHC class II expression by sheep afferent lymph dendritic cells. Comparison of primary and secondary immune responses.

The Journal of Experimental Medicine
J HopkinsI McConnell

Abstract

The experiments described in this article characterize the phenotypic and functional changes in afferent lymph cell populations that occur as a result of in vivo immune stimulation. During the primary immune response (in antigen-naive sheep) there are very transient increases in level of CD1 expression by subpopulations of dendritic cells (DC) but no alterations in cell kinetics or MHC class II expression. In contrast, secondary antigenic challenge (in primed sheep) into the drainage area of an afferent lymphatic causes profound changes in the cell output, characterized by a greater than threefold drop in total cell output on days 1-3 followed by an approximate fivefold rise on day 5. There is also a substantial increase in both the proportion of MHC class II-positive T lymphocytes (from 28 to 54%) and in the quantitative expression of class II by both DC and lymphocytes. Class II expression by DC increases five- to sixfold by day 5, while the level of expression of class II on lymphocytes approximately doubles. The increase in CD1 expression during the secondary response is more prolonged than during the primary response, being detectable between days 2 and 6 after challenge. The rise in class II affects the whole DC populatio...Continue Reading

References

Oct 1, 1989·The Journal of Experimental Medicine·R BujdosoI McConnell
Feb 1, 1987·The Journal of Experimental Medicine·S L KoideR M Steinman
Dec 1, 1986·Immunological Reviews·G F BottazzoR Pujol-Borrell
May 1, 1988·Scandinavian Journal of Immunology·N D MacHughA Kaushal
Jun 1, 1986·Immunological Reviews·M Miyasaka, Z Trnka
Mar 1, 1985·The Journal of Experimental Medicine·G Schuler, R M Steinman
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K OliverE S Vitetta
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E A Kurt-JonesE R Unanue
May 1, 1985·European Journal of Immunology·P M SnowC Terhorst
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A MatisR H Schwartz
Apr 1, 1983·The Journal of Experimental Medicine·J S PoberK A Ault
Feb 1, 1984·European Journal of Immunology·D I Beller
Nov 1, 1980·The Journal of Experimental Medicine·R M SteinmanI S Mellman
Dec 1, 1982·The Journal of Experimental Medicine·P S SteegJ J Oppenheim
Jun 1, 1983·The Journal of Experimental Medicine·C W PughH W Steer
Dec 1, 1982·European Journal of Immunology·S C KnightJ Clarke

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Citations

May 29, 1998·European Journal of Immunology·V K GuptaJ Hopkins
Jan 1, 1994·Cell and Tissue Research·M HallerakerT Landsverk
Jan 1, 1993·Veterinary Immunology and Immunopathology·D P LunnW P Duffus
Jan 1, 1993·The British Veterinary Journal·D P Lunn
Dec 30, 1999·Veterinary Immunology and Immunopathology·C WatkinsG D Harkiss
Mar 4, 2000·Veterinary Immunology and Immunopathology·J HopkinsS M Rhind
Apr 5, 2007·Nature Protocols·Simon W F MillingGordon MacPherson
May 8, 1999·Immunology·D M HaigH R Miller
Oct 1, 1989·The Journal of Experimental Medicine·R BujdosoI McConnell
Apr 1, 1996·The Journal of Experimental Medicine·J M Austyn
Mar 1, 1994·Tissue Antigens·M A Holmes, D P Lunn
Oct 12, 2000·Journal of Virology·S RyanB Blacklaws
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S CuzicR Waldherr
Jan 29, 2008·Developmental and Comparative Immunology·Caroline Piercey AkessonMona Aleksandersen
Feb 21, 2007·Scandinavian Journal of Immunology·K MatthewsJ Hopkins
Sep 20, 2005·Veterinary Immunology and Immunopathology·Anton GossnerJohn Hopkins
Apr 23, 2014·PloS One·Mi Ha KimIgor B Dawid
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A W BarrettD M Williams
Nov 8, 2007·Journal of Leukocyte Biology·Simon S M ChanBarbara A Blacklaws
Aug 1, 1995·European Journal of Immunology·E MichaëlssonR Holmdahl
Jan 1, 1991·Animal Genetics·E V DeversonJ C Howard
Jan 1, 1994·International Reviews of Immunology·R S Blumberg, S P Balk
Nov 1, 1990·European Journal of Immunology·G D HarkissI McConnell
Jan 1, 1990·International Reviews of Immunology·R BujdosoI McConnell
Dec 1, 1995·Clinical and Experimental Immunology·D J BrownE J Glass

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