In vivo modulation of foreign body response on polyurethane by surface entrapment technique

Journal of Biomedical Materials Research. Part a
Anand P KhandwekarMukesh Doble

Abstract

Implanted polymeric materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body response (FBR), which causes several complications. In this study, polyurethane (Tecoflex®, PU) surface modified with the nonionic surfactant Tween80® (PU/T80) and the cell adhesive PLL-RGD peptide (PU/PLL-RGD) by a previously described entrapment technique were implanted in the peritoneal cavity of Wistar rats for 30 days. Implants were retrieved and examined for tissue reactivity and cellular adherence by various microscopic and analytical techniques. Surface-induced inflammatory response was assessed by real-time PCR based quantification of proinflammatory cytokine transcripts, namely, TNF-α and IL-1β, normalized to housekeeping gene GAPDH. Cellular adherence and their distribution profile were assessed by microscopic examination of H&E stained implant sections. It was observed that PU/PLL-RGD followed by the bare PU surface exhibited severe inflammatory and fibrotic response with an average mean thickness of 19 and 12 μm, respectively, in 30 days. In contrast, PU/T80 surface showed only a cellular monolayer of 2-3 μm in thickness, with a mild inflammatory response and no fibrotic encapsula...Continue Reading

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Citations

Mar 26, 2011·Journal of Materials Science. Materials in Medicine·Anand P Khandwekar, Mukesh Doble
Nov 26, 2013·Advanced Drug Delivery Reviews·Paul de VosMarijke M Faas
Feb 9, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cynthya Maria Manohar, Mukesh Doble
Sep 14, 2011·Biotechnology Progress·Hai-Hua SunFa-Ming Chen
Nov 16, 2011·Journal of Biomedical Materials Research. Part a·Dongsheng TanQiang Fu
Apr 12, 2012·Journal of Biomedical Materials Research. Part a·Anand Khandwekar, Cho K Rho
Jul 16, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sebastian RiescherKarla Lehle
Jan 30, 2015·Journal of Biomedical Materials Research. Part a·Dongsheng TanQiang Fu
Mar 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dongsheng TanQiang Fu

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