PMID: 3744938Jul 1, 1986Paper

In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan

International Journal of Radiation Oncology, Biology, Physics
A RussoJ B Mitchell

Abstract

The effect of giving buthionine sulfoximine (BSO), 0.0265 g/mouse (6 mM), at 12 and 6 hr before treatment with melphalan--0.0 mg, 3 mg, 6 mg, and 9 mg/kg, was studied in C3H mice, and was compared with control groups that received normal saline 12 and 6 hr before identical melphalan treatment. BSO treatment resulted in depletion of GSH levels in bone marrow, liver, and muscle to 65, 13, and 41% of control levels, respectively. Hematological toxicity was assessed by measurement of CFU-S survival and peripheral white cell counts. CFU-S survival decreased with increasing doses of melphalan, but no difference was observed with BSO pre-treatment. Likewise, WBC counts following melphalan 9 mg/kg, were similar irrespective of BSO pre-treatment. These data suggest that the marrow toxicity seen with melphalan is not worsened by pre-treatment with BSO and that if tumors can be pre-sensitized with BSO, there may be a clinical role for melphalan/BSO drug combination.

Citations

Jan 1, 1991·Cancer Chemotherapy and Pharmacology·S X SkapekH S Friedman
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·V Jevtović-TodorovićV Jevtorić-Todorović
Jan 1, 1997·Free Radical Biology & Medicine·S M HahnJ B Mitchell
Nov 1, 2000·Nuclear Medicine and Biology·N ShimuraT Sasaki
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J B MitchellA Russo
Jan 1, 1990·Critical Reviews in Oncology/hematology·C N Coleman, A T Turrisi
Mar 1, 1989·Cancer Treatment Reviews·D J Stewart, W K Evans
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·A RussoJ B Mitchell
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J CarmichaelA Russo

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