In vivo modulation of plasma free fatty acids in patients with familial combined hyperlipidemia using lipid-lowering medication

The Journal of Clinical Endocrinology and Metabolism
S MeijssenM C Cabezas

Abstract

One of the best studied aspects of the insulin resistance syndrome in familial combined hyperlipidemia (FCHL) is impaired insulin-mediated suppression of FFA by diminished inhibition of hormone-sensitive lipase (HSL). In vitro experiments have shown that stimulation of HSL activity by catecholamines is decreased in FCHL. The aim of this study was to investigate HSL inhibition by insulin and stimulation by endogenous catecholamines in vivo in FCHL patients. Twelve FCHL subjects using lipid-lowering medication and 12 controls underwent a mental stress test after random ingestion of either 50 g glucose or placebo. After ingestion of glucose, insulin concentrations increased from 76.8 +/- 21.5 pM to a maximum of 520.2 +/- 118.4 pM (P < 0.01) in FCHL and from 38.0 +/- 5.0 to 221.7 +/- 25.1 pM (P < 0.01) in controls. The percent decreases in plasma FFA during the first hour after glucose ingestion were similar in FCHL and controls (67 +/- 5% vs. 72 +/- 3%, respectively), suggesting a comparable inhibition of HSL in both. During the placebo test, FFA increased similarly in FCHL (56 +/- 9%) and controls (57 +/- 19%). In contrast, FFA concentrations did not change during mental stress after ingestion of glucose (from 0.17 +/- 0.02 to 0....Continue Reading

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Citations

Oct 25, 2012·Journal of Nutrition and Metabolism·Manuel Castro CabezasBoudewijn Klop
Oct 1, 2011·International Journal of Vascular Medicine·Boudewijn KlopManuel Castro Cabezas
Jan 22, 2008·The British Journal of Nutrition·Andrew Abdel-SayedLuc Tappy

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